DDX58 Antikörper (AA 1-220)

Produktnummer ABIN5027276

Produktdetails anti-DDX58 Antikörper

Target: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Bindungsspezifität: AA 1-220

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DDX58 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant human RIG-I protein (amino acids 1-220) was used as the immunogen for this antibody.

Klon: ABM4H29

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL, IHC: 15 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu DDX58

Target: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Andere Bezeichnung: RIG-I (DDX58 Produkte)

Synonyme: RIG-I antikoerper, RIGI antikoerper, RLR-1 antikoerper, 6430573D20Rik antikoerper, C330021E21 antikoerper, RHIV-1 antikoerper, RIG-1 antikoerper, DExD/H-box helicase 58 antikoerper, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 antikoerper, DEXD/H-box helicase 58 antikoerper, DDX58 antikoerper, Ddx58 antikoerper

Hintergrund: RIG-I (retinoic-acid-inducible gene I), also known as DDX58 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 58) is a 925-residue cytoplasmic viral RNA receptor, critically involved in the activation of the innate immune response to RNA virus infection. It is a member of the RIG-I-like receptor (RLR) family and is an essential intracellular sensor for several 5-triphosphorylated RNA viruses. RIG-I elicits its antiviral interferon (IFN) responses by recognizing viral double-stranded RNAs (dsRNAs). Structurally it comprises a helicase domain, a C-terminal domain, and N-terminal CARDs (caspase activation recruitment domains) involved in activating MAVS (mitochondrial antiviral signaling protein). Upon binding of 5-triphosphorylated RNA, RIG-I undergoes conformational changes and post-translational modifications that allow multimerization and interaction with the mitochondrial antiviral signaling protein (MAVS).

Molekulargewicht: 106 kDa

Gen-ID: 23586

UniProt: O95786

Pathways: Activation of Innate immune Response, Hepatitis C