RASSF5 Antikörper (AA 321-418) (Alexa Fluor 680)

Produktnummer ABIN5009630

Produktdetails anti-RASSF5 Antikörper (Alexa Fluor 680)

Target: RASSF5 (Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5))

Bindungsspezifität: AA 321-418

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RASSF5 Antikörper ist konjugiert mit Alexa Fluor 680

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RASSF5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu RASSF5

Target: RASSF5 (Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5))

Andere Bezeichnung: RASSF5 (RASSF5 Produkte)

Synonyme: Maxp1 antikoerper, NORE1 antikoerper, NORE1A antikoerper, NORE1B antikoerper, RAPL antikoerper, RASSF3 antikoerper, 1300019G20Rik antikoerper, AU042887 antikoerper, Nore1 antikoerper, Nore1A antikoerper, Nore1B antikoerper, Rapl antikoerper, Ras association domain family member 5 antikoerper, Ras association (RalGDS/AF-6) domain family member 5 antikoerper, RASSF5 antikoerper, Rassf5 antikoerper

Hintergrund:

Synonyms: RAPL, Maxp1, NORE1, NORE1A, NORE1B, RASSF3, Ras association domain-containing protein 5, New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RASSF5

Background: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.

Gen-ID: 83593

UniProt: Q8WWW0

Pathways: T-Zell Rezeptor Signalweg