RASSF5 Antikörper (AA 321-418)

Produktnummer ABIN1386228

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-RASSF5 Antikörper (ABIN1386228) detektiert spezifisch RASSF5 in IF (cc), IF (p), IHC (fro) und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für RASSF5 Antikörper (AA 321-418) (ABIN1386228)

Target: RASSF5 (Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RASSF5 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-RASSF5 Antikörper

Bindungsspezifität: AA 321-418

Verwendungszweck: RASSF5 Polyclonal Antibody

Homologie: Human,Mouse,Rat,Dog,Cow,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RASSF5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-RASSF5 Antikörper (ABIN1386228)

Yang, Kong, Jin, Hergovich, Püschel: "Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway." in: Journal of cell science, Vol. 127, Issue Pt 16, pp. 3463-76, (2014) (PubMed).

Details zu RASSF5

Target: RASSF5 (Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5))

Andere Bezeichnung: RASSF5

Hintergrund:

Synonyms: RAPL, Maxp1, NORE1, NORE1A, NORE1B, RASSF3, Ras association domain-containing protein 5, New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RASSF5

Background: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.

Gen-ID: 83593

UniProt: Q8WWW0

Pathways: T-Zell Rezeptor Signalweg