Presenilin 1 Antikörper (AA 321-430) (Alexa Fluor 750)
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- Target Alle Presenilin 1 (PSEN1) Antikörper anzeigen
- Presenilin 1 (PSEN1)
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Bindungsspezifität
- AA 321-430
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Reaktivität
- Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Presenilin 1 Antikörper ist konjugiert mit Alexa Fluor 750
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Applikation
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Maus, Ratte
- Homologie
- Human,Chicken
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Presenilin-1/ Presenilin-2
- Isotyp
- IgG
- Top Product
- Discover our top product PSEN1 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- Presenilin 1 (PSEN1)
- Andere Bezeichnung
- Presenilin 1 (PSEN1 Produkte)
- Synonyme
- pre1 antikoerper, psen antikoerper, zfPS1 antikoerper, zf-PS1 antikoerper, ad3 antikoerper, fad antikoerper, ps1 antikoerper, s182 antikoerper, X-PS-beta antikoerper, X-PS-alpha antikoerper, AD3 antikoerper, FAD antikoerper, PS-1 antikoerper, PS1 antikoerper, S182 antikoerper, Ad3h antikoerper, presenilin 1 antikoerper, presenilin 1 L homeolog antikoerper, psen1 antikoerper, PSEN1 antikoerper, Psen1 antikoerper, psen1.L antikoerper
- Hintergrund
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Synonyms: AD 3, AD4, AD5, Alzheimer disease 3, Alzheimer disease 4, FAD, Presenilin 1, Presenilin 2, Presenilin-1, Presenilin-2, Presenilin1, Presenilin1, PS1, PS2, PS-1, PS-2, PSEN1, PSEN2, STM2, PSN1_HUMAN, PSN2_HUMAN.
Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP.
- Pathways
- Notch Signalweg, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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