FANCM Antikörper (AA 831-930) (Alexa Fluor 750)

Produktnummer ABIN5002460

Produktdetails anti-FANCM Antikörper (Alexa Fluor 750)

Target: FANCM (Fanconi Anemia Complementation Group M (FANCM))

Bindungsspezifität: AA 831-930

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FANCM Antikörper ist konjugiert mit Alexa Fluor 750

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FANCM

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu FANCM

Target: FANCM (Fanconi Anemia Complementation Group M (FANCM))

Andere Bezeichnung: FANCM (FANCM Produkte)

Synonyme: FAAP250 antikoerper, KIAA1596 antikoerper, AI427100 antikoerper, C730036B14Rik antikoerper, D12Ertd364e antikoerper, Fanconi anemia complementation group M antikoerper, hypothetical protein antikoerper, Fanconi anemia, complementation group M antikoerper, FANCM antikoerper, PGTG_17854 antikoerper, Fancm antikoerper

Hintergrund:

Synonyms: FAAP250, Fanconi anemia group M protein, Protein Hef ortholog,

Background: Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. The thirteen FA proteins that have been characterized are important for regulating chromosomal stability and genome surveillance. Eight of these proteins, namely FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL and FANCM, comprise the FA core complex, which catalyzes a key reaction in DNA repair: the monoubiquitination of FANCD2. FANCM (Fanconi anemia, complementation group M) is a member of the DEAD-box helicase family of proteins and contains a DEAH helicase domain and a nuclease domain. Localizing to chromatin fractions, FANCM is phosphorylated in a cell cycle-dependent manner and is believed to function as an anchor, recruiting the FA core complex to chromatin. Mutations in the gene encoding FANCM can lead to Fanconi anemia.

Gen-ID: 57697

Pathways: DNA Reparatur