DPYSL4 Antikörper

Produktnummer ABIN499060

Produktdetails anti-DPYSL4 Antikörper

Target: DPYSL4 (Dihydropyrimidinase-Like 4 (DPYSL4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DPYSL4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects endogenous levels of CRMP-3 protein. (region surrounding Cys132)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu DPYSL4

Target: DPYSL4 (Dihydropyrimidinase-Like 4 (DPYSL4))

Andere Bezeichnung: DPYSL4 / CRMP3 (DPYSL4 Produkte)

Synonyme: CRMP3A antikoerper, CRMP3B antikoerper, crmp3 antikoerper, crmp3-a antikoerper, MGC53768 antikoerper, DPYSL4 antikoerper, drp-4 antikoerper, ulip4 antikoerper, CRMP-3 antikoerper, CRMP3 antikoerper, DRP-4 antikoerper, ULIP4 antikoerper, AI173505 antikoerper, Crmp3 antikoerper, DPY4 antikoerper, Drp-4 antikoerper, Ulip4 antikoerper, Dpys4 antikoerper, dihydropyrimidinase like 4 antikoerper, dihydropyrimidinase like 4 L homeolog antikoerper, dihydropyrimidinase-like 4 antikoerper, DPYSL4 antikoerper, dpysl4.L antikoerper, dpysl4 antikoerper, Dpysl4 antikoerper

Hintergrund: Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to Semaphorin 3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-3 is expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. It is cleaved by Calpain to produce a p54 N-terminal fragment. This cleavage product translocates to the nucleus and induces neuronal death in response to excitotoxicity and cerebral ischemia.Synonyms: Collapsin response mediator protein 3, DRP-4, Dihydropyrimidinase-related protein 4, ULIP4, UNC33-like phosphoprotein 4

Molekulargewicht: approx. 50 kDa

Gen-ID: 10570

NCBI Accession: NP_006417

UniProt: O14531