Der Kaninchen Polyklonal anti-DPYSL4 Antikörper (ABIN7073734) detektiert spezifisch DPYSL4 in IHC und IF.
Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Target
DPYSL4
(Dihydropyrimidinase-Like 4 (DPYSL4))
Andere Bezeichnung
CRMP3
Hintergrund
CRMP-3 is expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. It is cleaved by Calpain to produce a p54 N-terminal fragment. This cleavage product translocates to the nucleus and induces neuronal death in response to excitotoxicity and cerebral ischemia. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.