KDELR2 Antikörper

Produktnummer ABIN498960

Produktdetails anti-KDELR2 Antikörper

Target: KDELR2 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 2 (KDELR2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDELR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of KDEL Receptor 2 protein. (region surrounding Leu119)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu KDELR2

Target: KDELR2 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 2 (KDELR2))

Andere Bezeichnung: KDEL Receptor 2 / KDELR2 (KDELR2 Produkte)

Synonyme: kdelr2 antikoerper, ELP-1 antikoerper, ERD2.2 antikoerper, 1110007A14Rik antikoerper, kdelr1-a antikoerper, KDEL endoplasmic reticulum protein retention receptor 2 L homeolog antikoerper, KDEL endoplasmic reticulum protein retention receptor 2 antikoerper, KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 antikoerper, KDEL endoplasmic reticulum protein retention receptor 1 L homeolog antikoerper, kdelr2.L antikoerper, KDELR2 antikoerper, Kdelr2 antikoerper, kdelr1.L antikoerper

Hintergrund: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-gluleu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.Synonyms: ELP-1, ER lumen protein retaining receptor 2, ERD2-like protein 1, ERD2.2, KDEL endoplasmic reticulum protein retention receptor 2

Molekulargewicht: approx. 24 kDa

Gen-ID: 11014

NCBI Accession: NP_006845

UniProt: P33947

Pathways: Maintenance of Protein Location