KDELR2 Antikörper (C-Term)

Produktnummer ABIN953024

Produktdetails anti-KDELR2 Antikörper

Target: KDELR2 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 2 (KDELR2))

Bindungsspezifität: AA 182-211, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDELR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes Human KDEL Receptor 2 / KDELR2 (C-term).

Aufreinigung: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 182-211 amino acids from the C-terminal region of human KDELR2

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu KDELR2

Target: KDELR2 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 2 (KDELR2))

Andere Bezeichnung: KDEL Receptor 2 / KDELR2 (KDELR2 Produkte)

Synonyme: kdelr2 antikoerper, ELP-1 antikoerper, ERD2.2 antikoerper, 1110007A14Rik antikoerper, kdelr1-a antikoerper, KDEL endoplasmic reticulum protein retention receptor 2 L homeolog antikoerper, KDEL endoplasmic reticulum protein retention receptor 2 antikoerper, KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 antikoerper, KDEL endoplasmic reticulum protein retention receptor 1 L homeolog antikoerper, kdelr2.L antikoerper, KDELR2 antikoerper, Kdelr2 antikoerper, kdelr1.L antikoerper

Hintergrund: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83 % identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].Synonyms: ELP-1, ER lumen protein retaining receptor 2, ERD2-like protein 1, ERD2.2, KDEL endoplasmic reticulum protein retention receptor 2

Molekulargewicht: 24422 Da

Gen-ID: 11014

NCBI Accession: NP_001094073

Pathways: Maintenance of Protein Location