HDAC1 Antikörper

Produktnummer ABIN498934

Produktdetails anti-HDAC1 Antikörper

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of HDAC1 protein. (region surrounding Glu427)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu HDAC1

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Andere Bezeichnung: HDAC1 (HDAC1 Produkte)

Synonyme: GON-10 antikoerper, HD1 antikoerper, RPD3 antikoerper, RPD3L1 antikoerper, CG7471 antikoerper, DHDAC1 antikoerper, DRpd3 antikoerper, DmHDAC1 antikoerper, Dmel\\CG7471 antikoerper, E(var)3-64BC antikoerper, HDAC antikoerper, HDAC-1 antikoerper, HDAC1 antikoerper, Hdac1 antikoerper, Rpd3/HDAC antikoerper, Su(var)3-26 antikoerper, Su(var)326 antikoerper, Su(var)328 antikoerper, dHDAC-1 antikoerper, dHDAC1 antikoerper, dRPD3 antikoerper, dRpd3 antikoerper, dmHDA401 antikoerper, drpd3 antikoerper, hdac1 antikoerper, l(3)04556 antikoerper, l(3)64Cc antikoerper, rpd3 antikoerper, rpd[3] antikoerper, gon-10 antikoerper, hdac1b antikoerper, rpd3l1 antikoerper, Rpd3 antikoerper, GB14706 antikoerper, hdac1-b antikoerper, chunp6919 antikoerper, hdac-1 antikoerper, mp:zf637-2-001987 antikoerper, wu:fb19h11 antikoerper, wu:fi06f03 antikoerper, zgc:101582 antikoerper, zgc:65818 antikoerper, Hdac1-ps antikoerper, MommeD5 antikoerper, ARABIDOPSIS HISTONE DEACETYLASE 1 antikoerper, ARABIDOPSIS HISTONE DEACETYLASE 19 antikoerper, ATHD1 antikoerper, ATHDA19 antikoerper, ATRPD3A antikoerper, F20D10.250 antikoerper, F20D10_250 antikoerper, HDA1 antikoerper, HDA19 antikoerper, HISTONE DEACETYLASE antikoerper, HISTONE DEACETYLASE 19 antikoerper, HISTONE DEACETYLASE19 antikoerper, RPD3A antikoerper, histone deacetylase 1 antikoerper, HDM antikoerper, ab21 antikoerper, hdac1a antikoerper, histone deacetylase 1 antikoerper, Histone deacetylase 1 antikoerper, histone deacetylase antikoerper, histone deacetylase 1 S homeolog antikoerper, histone deacetylase Rpd3 antikoerper, histone deacetylase 1 L homeolog antikoerper, HDAC1 antikoerper, hdac1.S antikoerper, LOC411503 antikoerper, hdac1 antikoerper, Hdac1 antikoerper, HD1 antikoerper, hda-1 antikoerper, hdac1.L antikoerper, LOC748850 antikoerper

Hintergrund: In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.Synonyms: HD1, Histone deacetylase 1, RPD3L1

Molekulargewicht: approx. 55 kDa

Gen-ID: 3065

NCBI Accession: NP_004955

UniProt: Q13547

Pathways: Neurotrophin Signalübertragung, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis