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EIF2S1 Antikörper (pSer51)
EIF2S1
Reaktivität: Human, Ratte, Maus
WB, IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-EIF2S1 Antikörper
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Target
Alle EIF2S1 Antikörper anzeigen
EIF2S1
(Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1))
Bindungsspezifität
Alle Epitope für EIF2S1 Antikörper
pSer51
Reaktivität
Alle Reaktivitäten für EIF2S1 Antikörper
Human, Ratte, Maus
Wirt
Alle Wirte für EIF2S1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für EIF2S1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für EIF2S1 Antikörper
Dieser EIF2S1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für EIF2S1 Antikörper
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Spezifität
This antibody detects endogenous levels of eIF2alpha protein only when phosphorylated at Ser51.
Kreuzreaktivität (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Aufreinigung
Affinity chromatography
Reinheit
> 95 % by SDS-PAGE
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Anwendungsinformationen
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Applikationshinweise
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu EIF2S1
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Target
EIF2S1
(Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1))
Andere Bezeichnung
EIF2A / EIF2S1 (EIF2S1 Produkte )
Synonyme
EIF-2 antikoerper, EIF-2A antikoerper, EIF-2alpha antikoerper, EIF2 antikoerper, EIF2A antikoerper, Eif2s1 antikoerper, eif2s1l antikoerper, fb36a08 antikoerper, wu:fb36a08 antikoerper, zgc:56510 antikoerper, 0910001O23Rik antikoerper, 2410026C18Rik antikoerper, 35kDa antikoerper, Eif2a antikoerper, eIF2alpha antikoerper, eif2a antikoerper, CG9946 antikoerper, Dmel\\CG9946 antikoerper, Eif2alpha antikoerper, IF2A_DROME antikoerper, M(1)14C antikoerper, M(1)19-153 antikoerper, M(1)8e3-10 antikoerper, deIF2alpha antikoerper, eIF-2 antikoerper, eIF-2 a antikoerper, eIF-2 alpha antikoerper, eIF2 alpha antikoerper, eIF2-alpha antikoerper, eIF2a antikoerper, eiF-2alpha antikoerper, elF2alpha antikoerper, l(1)14Cf antikoerper, l(1)19-153 antikoerper, eukaryotic translation initiation factor 2 subunit alpha antikoerper, eukaryotic translation initiation factor 2, subunit 1 alpha a antikoerper, eukaryotic translation initiation factor 2, subunit 1 alpha antikoerper, eukaryotic translation initiation factor 2 alpha subunit antikoerper, Eukaryotic translation initiation factor 2 subunit 1 antikoerper, eukaryotic translation initiation factor 2 subunit alpha L homeolog antikoerper, eukaryotic translation Initiation Factor 2alpha antikoerper, EIF2S1 antikoerper, eif2s1a antikoerper, Eif2s1 antikoerper, eif2s1 antikoerper, LOC693063 antikoerper, CNI00230 antikoerper, THAPSDRAFT_105 antikoerper, if2a antikoerper, eif2s1.L antikoerper, eIF-2alpha antikoerper
Hintergrund
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) is known to be an important translational control mechanism. Regulation of mammalian eIF2alpha activity is directly governed by specific phosphorylation on Serine 52. In mammalian cells, eIF2alpha is phosphorylated at Serine 52 by at least two kinases, the haem-controlled repressor and the interferon-inducible double stranded RNA-dependent protein kinase. This phosphorylation event results in an inhibition in the exchange of bound nucleotides and the recycling of eIF2alpha. In addition, phosphorylation of eIF2alpha blocks the GDP-GTP exchange activity of eIF2beta, resulting in the suppression of protein synthesis.Synonyms: EIF2-A, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, eIF2 alpha
Molekulargewicht
approx. 38 kDa
Gen-ID
1965
NCBI Accession
NP_004085
UniProt
P05198
Pathways
Ribonucleoprotein Complex Subunit Organization , ER-Nucleus Signaling , Hepatitis C
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