FOXO3 Antikörper (pSer253)
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- Target Alle FOXO3 Antikörper anzeigen
- FOXO3 (Forkhead Box O3 (FOXO3))
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Bindungsspezifität
- pSer253
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FOXO3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects endogenous levels of FoxO3 protein when phosphorylated at Serine 253
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human and Mouse.
- Aufreinigung
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product FOXO3 Primärantikörper
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- Applikationshinweise
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Western Blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH ~7.2, 15 mM Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- FOXO3 (Forkhead Box O3 (FOXO3))
- Andere Bezeichnung
- FOXO3 / FKHRL1 (FOXO3 Produkte)
- Synonyme
- AF6q21 antikoerper, FKHRL1 antikoerper, FKHRL1P2 antikoerper, FOXO2 antikoerper, FOXO3A antikoerper, zgc:92176 antikoerper, wu:fb50g02 antikoerper, wu:fi33f07 antikoerper, Fkhrl1 antikoerper, Foxo3a antikoerper, FoxO3A antikoerper, 1110048B16Rik antikoerper, 2010203A17Rik antikoerper, C76856 antikoerper, Fkhr2 antikoerper, FOXO-3 antikoerper, FOXO3 antikoerper, foxo3a antikoerper, xfoxo3 antikoerper, foxO3 antikoerper, foxO antikoerper, fkhr antikoerper, foxo5 antikoerper, wu:fj65a12 antikoerper, zFkhr antikoerper, forkhead box O3 antikoerper, forkhead box O3A antikoerper, forkhead box O3 L homeolog antikoerper, forkhead box O3b antikoerper, FOXO3 antikoerper, foxo3a antikoerper, Foxo3 antikoerper, foxo3.L antikoerper, foxo3 antikoerper, foxO3 antikoerper, foxo3b antikoerper
- Hintergrund
- FOXO3A belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Forkhead transcription factors of the FoxO subfamily are emerging as a shared component among pathways regulating diverse cellular functions, such as differentiation, metabolism, proliferation, and survival. Their transcriptional output is controlled via a two-tiered mechanism of phosphorylation and acetylation.FOXO3A is a transcriptional activator which triggers apoptosis in the absence of survival factors. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. FOXO3a has been shown to induce cell growth arrest to effect tumor suppression and FOXO3A genotype is strongly associated with human longevity.Synonyms: AF6q21 protein, FOXO3A, Forkhead box protein O3, Forkhead in rhabdomyosarcoma-like 1
- Molekulargewicht
- approx. 97 kDa
- Gen-ID
- 2309
- NCBI Accession
- NP_001446
- UniProt
- O43524
- Pathways
- Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis
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