Aromatase Antikörper

Produktnummer ABIN498440

Produktdetails anti-Aromatase Antikörper

Target: Aromatase (CYP19A1) (Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Aromatase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Spezifität: This antibody detects endogenous levels of CYP19A1 protein. (region surrounding Lys243)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500-1/1000. Immunofluorescence 1/50-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Aromatase

Target: Aromatase (CYP19A1) (Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1))

Andere Bezeichnung: Aromatase (CYP19A1 Produkte)

Synonyme: ARO antikoerper, ARO1 antikoerper, CPV1 antikoerper, CYAR antikoerper, CYP19 antikoerper, CYPXIX antikoerper, P-450AROM antikoerper, Aromatase antikoerper, Cyp19 antikoerper, Cyp19a antikoerper, p450arom antikoerper, P450 arom antikoerper, aro antikoerper, cyp19 antikoerper, cyp19a antikoerper, p450arom-A antikoerper, P450AROM antikoerper, Ar antikoerper, ArKO antikoerper, Int-5 antikoerper, Int5 antikoerper, CYP19P1 antikoerper, CYP19A1 antikoerper, CYP19a1 antikoerper, P450aromA antikoerper, ar1 antikoerper, cypXIX antikoerper, etID309862.18 antikoerper, zgc:136541 antikoerper, AroB antikoerper, CYP19a2 antikoerper, P450aromB antikoerper, cyp19b antikoerper, zgc:92614 antikoerper, cyp19a1 antikoerper, cytochrome P450 family 19 subfamily A member 1 antikoerper, cytochrome P450, family 19, subfamily a, polypeptide 1 antikoerper, cytochrome P450 family 19 subfamily A member 1 L homeolog antikoerper, aromatase antikoerper, cytochrome P450 aromatase antikoerper, cytochrome P450, family 19, subfamily A, polypeptide 1 antikoerper, cytochrome P450 19A1 antikoerper, cytochrome P450, family 17, subfamily A, polypeptide 1 antikoerper, cytochrome P450, family 19 antikoerper, cytochrome P450, family 19, subfamily A, polypeptide 1a antikoerper, cytochrome P450, family 19, subfamily A, polypeptide 1b antikoerper, cytochrome P450 19A1-like antikoerper, CYP19A1 antikoerper, Cyp19a1 antikoerper, cyp19a1.L antikoerper, SAV_2383 antikoerper, pfcyp19b-tstr antikoerper, CYP19 antikoerper, cyp19a1a antikoerper, cyp19a1b antikoerper, LOC101174651 antikoerper

Hintergrund: P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. P450 enzymes can be classified, based on their sequence similarities, into distinct subfamilies, which include CYP1A and CYP2A. Other P450 family members include CYP19, also designated aromatase (P450arom), which catalyzes the conversion of C19 steroids to estrogens in various tissues, including placent,a gonads, adipose tissue, skin and brain. CYP19 expression is controlled by hormonally regulated promoters in different tissues and increased aromatase activity is associated with familial gynecomastia. Also, a polymorphic allele of CYP19 (repeat (TTTA)12) is present in a majority of breast cancer patients. P450 cholesterol 7α-hydroxylase, CYP7A1, is the rate limiting enzyme of bile acid synthesis in the liver, and its expression is mediated by the bile acid receptor FXR. CYP27A1 catalyzes vitamin D 25-hydroxylation and is localized to the mitochondria in kidney and liver.Synonyms: ARO1, CYAR, CYP19, CYP19A1, CYPXIX, Cytochrome P450 19A1, Estrogen synthetase, P450AROM

Molekulargewicht: approx. 58 kDa

Gen-ID: 1588

NCBI Accession: NP_000094

UniProt: P11511

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process, Carbohydrate Homeostasis