Nibrin Antikörper

Produktnummer ABIN498402

Produktdetails anti-Nibrin Antikörper

Target: Nibrin (NBN)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nibrin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Spezifität: This antibody detects endogenous levels of NBS1 protein. (region surrounding Gly274)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Nibrin

Target: Nibrin (NBN)

Andere Bezeichnung: Nibrin (NBN Produkte)

Synonyme: NBN antikoerper, AT-V1 antikoerper, AT-V2 antikoerper, ATV antikoerper, NBS antikoerper, NBS1 antikoerper, P95 antikoerper, Nbs1 antikoerper, im:6911679 antikoerper, zgc:194152 antikoerper, nibrin antikoerper, NBN antikoerper, nbn antikoerper, Nbn antikoerper

Hintergrund: The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex (MRN complex). This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions. In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells. NBS1 is expressed ubiquitously and presents high levels in testis.Synonyms: Cell cycle regulatory protein p95, NBN, NBS, NBS1, Nijmegen breakage syndrome protein 1, P95

Molekulargewicht: approx. 95 kDa

Gen-ID: 4683

NCBI Accession: NP_002476

UniProt: O60934

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response