PFKFB1 Antikörper
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- Target Alle PFKFB1 Antikörper anzeigen
- PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PFKFB1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects endogenous levels of PFK-2 liv protein. (region surrounding Glu442)
- Kreuzreaktivität (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Aufreinigung
- Affinity-Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product PFKFB1 Primärantikörper
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- Applikationshinweise
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Western Blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH ~7.2 containing 15 mM Sodium Azide as preservative.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))
- Andere Bezeichnung
- PFKFB1 (PFKFB1 Produkte)
- Synonyme
- zgc:55328 antikoerper, wu:fi11h10 antikoerper, PFKFB1 antikoerper, F6PK antikoerper, HL2K antikoerper, PFRX antikoerper, Pfkfb01 antikoerper, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 antikoerper, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 S homeolog antikoerper, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 antikoerper, pfkfb1 antikoerper, PFKFB1 antikoerper, pfkfb1.S antikoerper, LOC100475853 antikoerper, Pfkfb1 antikoerper
- Hintergrund
- Phosphofructokinases (PFK) are regulatory glycolytic enzymes that convert fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2), and ADP. Human PFK-1 is tetrameric and isoenzymes include, PFK-1 muscle (PFKM, PFK-A), PFK-1 liver (PFKL, PFK-B), and PFK-1 platelet (PFKP, PFK-C, PFKF). PFK-1 is inhibited by ATP and citrate (from the tricarboxylic acid cycle). PFK-1 undergoes activation in the presence of elevated AMP. The most potent activator is fructose-2,6-bisphosphate, which is produced by PFK-2 from the same substrate, fructose 6-phosphate. PFK-2 is bifunctional and a key regulator for PFK-1. PFK-2 catalyzes the synthesis of fructose-2,6-bisphosphate, and contains fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. PFK-2 is dimeric and isoenzymes include PFK-2 liver (PFKFB1, PFRX), PFK-2 cardiac (PFKFB2), PFK-2 placental (PFKFB3, inducible PFK-2) and PFK-2 testis (PFKFB4).Synonyms: 6-biphosphatase 1, 6-phosphofructo-2-kinase/fructose-2, F6PK, PFK-2 liver, PFK/FBPase 1, PFRX
- Molekulargewicht
- approx. 52 kDa
- Gen-ID
- 5207
- NCBI Accession
- NP_002616
- UniProt
- P16118
- Pathways
- Regulation of Carbohydrate Metabolic Process
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