CPT2 Antikörper (Internal Region)

Produktnummer ABIN498063

Produktdetails anti-CPT2 Antikörper

Target: CPT2 (Carnitine Palmitoyltransferase 2 (CPT2))

Bindungsspezifität: AA 141-154, Internal Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser CPT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-PKSEYNDQLT RATN

Spezifität: Recognizes Carnitine O-palmitoyltransferase CPT2

Kreuzreaktivität (Details): Species reactivity (expected):Rat, Canine (Dog), Bovine, Pig.
Species reactivity (tested):Human, Mouse.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide from the internal region of Human CPT2 according to NP_000089.1. Genename: CPT2

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Detection Limit: 1/8000. Western blot: 1-3 μg/mL. Detects a band of Approx 70 kDa in Human and Mouse Liver lysates. An additional band of unknown identity was also consistently observed at 20 kDa. Thisband was successfully blocked by incubation with the immunizing peptide.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CPT2

Target: CPT2 (Carnitine Palmitoyltransferase 2 (CPT2))

Andere Bezeichnung: CPT2 (CPT2 Produkte)

Synonyme: CPT1 antikoerper, CPTASE antikoerper, IIAE4 antikoerper, AI323697 antikoerper, CPTII antikoerper, cg2107 antikoerper, wu:fa03e08 antikoerper, wu:fb54a02 antikoerper, zgc:101627 antikoerper, carnitine palmitoyltransferase 2 antikoerper, carnitine O-palmitoyltransferase 2, mitochondrial antikoerper, carnitine palmitoyltransferase 2 S homeolog antikoerper, CPT2 antikoerper, LOC100214547 antikoerper, Cpt2 antikoerper, cpt2.S antikoerper, cpt2 antikoerper

Hintergrund: Carnitine palmitoyltransferase II (CPT2) together with carnitine palmitoyltransferase I oxidizes long-chain fatty acids in the mitochondria. Defects in CPT2 are the cause of carnitine palmitoyltransferase 2 deficiency (CPT2D) also known as CPT-II deficiency or CPT2 deficiency. CPT2D is an autosomal recessive disorder characterized by recurrent myoglobinuria, episodes of muscle pain, stiffness, and rhabdomyolysis. These symptoms are triggered by prolonged exercise, fasting or viral infection and patients are usually young adults. In addition to this classical, late-onset, muscular type, a hepatic or hepatocardiomuscular form has been reported in infants. Clinical pictures in these children or neonates include hypoketotic hypoglycemia, liver dysfunction, cardiomyopathy and sudden death.Synonyms: CPT II, Carnitine O-palmitoyltransferase 2, Carnitine palmitoyltransferase II, mitochondrial

Gen-ID: 1376

NCBI Accession: NP_000089

UniProt: P23786

Pathways: Regulation of Lipid Metabolism by PPARalpha, Monocarboxylic Acid Catabolic Process