GNAS Antikörper (Internal Region)

Produktnummer ABIN498036

Produktdetails anti-GNAS Antikörper

Target: GNAS (GNAS Complex Locus (GNAS))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser GNAS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-QAARSNSDGE KATK

Spezifität: This antibody is expected to recognize all three reported isoforms NP_000507.1, NP_001070956.1 and NP_536350.2.

Kreuzreaktivität (Details): Species reactivity (expected):Bovine.
Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_000507.1, NP_001070956.1, NP_001070957.1. Genename: GNAS

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Limit Dilution: 1/16000. Western blot: 1-3 μg/mL. Approx 45 kDa band observed in lysates of cell line Jurkat(calculated MW of 45.5 kDa according to NP_000507.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GNAS

Target: GNAS (GNAS Complex Locus (GNAS))

Andere Bezeichnung: GNAS / GSP (GNAS Produkte)

Synonyme: AHO antikoerper, C20orf45 antikoerper, GNAS1 antikoerper, GPSA antikoerper, GSA antikoerper, GSP antikoerper, NESP antikoerper, PHP1A antikoerper, PHP1B antikoerper, PHP1C antikoerper, POH antikoerper, GNAS antikoerper, PORGSA1 antikoerper, G-alpha-S antikoerper, 5530400H20Rik antikoerper, A930027G11Rik antikoerper, C130027O20Rik antikoerper, Galphas antikoerper, Gnas1 antikoerper, Gnasxl antikoerper, Gsa antikoerper, Nesp antikoerper, Nespl antikoerper, Oed-Sml antikoerper, Oedsml antikoerper, P1 antikoerper, P2 antikoerper, P3 antikoerper, G-alpha-s antikoerper, gnas-a antikoerper, Gnpas antikoerper, Nesp55 antikoerper, gnal antikoerper, Gnas antikoerper, GNAS complex locus antikoerper, guanine nucleotide-binding protein G(s) subunit alpha antikoerper, GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus antikoerper, GNAS complex locus S homeolog antikoerper, neuroendocrine secretory protein 55-like antikoerper, GNAS antikoerper, LOC694289 antikoerper, LOC469986 antikoerper, Gnas antikoerper, gnas.S antikoerper, gnas antikoerper, LOC100346323 antikoerper, LOC100442753 antikoerper, LOC100732436 antikoerper

Hintergrund: GTP-binding proteins (G-proteins)are a family of heterotrimeric proteins that play a critical role in signal transduction by coupling cell surface, 7-transmembrane domain receptors to intracellular signaling pathways including second messenger generation (such as cyclic AMP, calcium and diacylglycerol), protein phosphorylation, ion channel activation, gene induction, cell growth and differentiation. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit.Synonyms: Adenylate cyclase-stimulating G alpha protein, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Gen-ID: 2778

NCBI Accession: NP_000507

UniProt: P63092

Pathways: Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Embryonic Body Morphogenesis