SREBF2 Antikörper (AA 399-427)
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- Target Alle SREBF2 Antikörper anzeigen
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
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Bindungsspezifität
- AA 399-427
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SREBF2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Aufreinigung
- Antigen affinity purified
- Immunogen
- A portion of amino acids 399-427 from the human protein was used as the immunogen for this SREBP2 antibody.
- Isotyp
- Ig Fraction
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- Applikationshinweise
- Titration of the SREBP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Immunofluorescence: 1:10-1:50,Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Aliquot the SREBP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
- Andere Bezeichnung
- SREBP2 (SREBF2 Produkte)
- Synonyme
- SREBF2 antikoerper, srebp2 antikoerper, SREBP2 antikoerper, zgc:158371 antikoerper, AI608257 antikoerper, SREBP-2 antikoerper, SREBP2gc antikoerper, bHLHd2 antikoerper, lop13 antikoerper, nuc antikoerper, Srebf2_retired antikoerper, sterol regulatory element binding transcription factor 2 antikoerper, sterol regulatory element binding factor 2 antikoerper, sterol regulatory element binding transcription factor 2 L homeolog antikoerper, SREBF2 antikoerper, srebf2 antikoerper, Srebf2 antikoerper, srebf2.L antikoerper
- Hintergrund
- SREBPs, including SREBP-1a, SREBP-1c, and SREBP-2, constitute a family of basic helix-loop-helix (bHLH) transcription factors that play a critical role in lipid homeostasis by regulating genes involved in cholesterol and fatty acid metabolism. Each SREBP consists of three domains, including an amino-terminal transcription factor domain of ~480 amino acids, a middle hydrophobic region of ~80 amino acids containing two hydrophobic transmembrane segments, and a carboxy-terminal regulatory domain of ~590 amino acids. SREBP-2 regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway. SREBP-2 is ubiquitously detected in various tissues. Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (about 50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol.
- UniProt
- Q12772
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
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