SREBF2 Antikörper (Middle Region)
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- Target Alle SREBF2 Antikörper anzeigen
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
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Bindungsspezifität
- AA 402-431, Middle Region
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SREBF2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Spezifität
- This antibody recognizes SREBF2 / SREBP2.
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human
- Aufreinigung
- Purified through a Protein A column followed by peptide affinity purification
- Immunogen
- Synthetic peptide - KLH conjugated - corresponding to the central region (between 402-431aa) of human SREBF2 / SREBP2
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product SREBF2 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.25 mg/mL
- Buffer
- PBS with 0.09 % (W/V) Sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
- Andere Bezeichnung
- SREBF2 / SREBP2 (SREBF2 Produkte)
- Synonyme
- SREBF2 antikoerper, srebp2 antikoerper, SREBP2 antikoerper, zgc:158371 antikoerper, AI608257 antikoerper, SREBP-2 antikoerper, SREBP2gc antikoerper, bHLHd2 antikoerper, lop13 antikoerper, nuc antikoerper, Srebf2_retired antikoerper, sterol regulatory element binding transcription factor 2 antikoerper, sterol regulatory element binding factor 2 antikoerper, sterol regulatory element binding transcription factor 2 L homeolog antikoerper, SREBF2 antikoerper, srebf2 antikoerper, Srebf2 antikoerper, srebf2.L antikoerper
- Hintergrund
- SREBPs, including SREBP-1a, SREBP-1c, and SREBP-2, constitute a family of basic helix-loop-helix (bHLH) transcription factors that play a critical role in lipid homeostasis by regulating genes involved in cholesterol and fatty acid metabolism. Each SREBP consists of three domains, including an amino-terminal transcription factor domain of ~480 amino acids, a middle hydrophobic region of ~80 amino acids containing two hydrophobic transmembrane segments, and a carboxy-terminal regulatory domain of ~590 amino acids. SREBP-2 regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway. SREBP-2 is ubiquitously detected in various tissues. Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (about 50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol. LS-B1609 polyclonal antibody detects both precursor and active forms of the protein in tissues and cells such as liver, brown fat, testis, Hep-G2 cells, and human fibroblast. The apparent molecular weight on SDS-PAGE may be higher than the calculated molecular weight (about 126 kDa) due to glycosylation of the protein.Synonyms: BHLHD2, Class D basic helix-loop-helix protein 2, SREBP-2, Sterol regulatory element-binding protein 2, Sterol regulatory element-binding transcription factor 2
- Gen-ID
- 6721
- NCBI Accession
- NP_004590
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
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