FYN Antikörper

Produktnummer ABIN3031012

Produktdetails anti-FYN Antikörper

Target: FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FYN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Aufreinigung: Purified

Immunogen: This FYN antibody was produced from a mouse immunized with a recombinant preotein from human FYN.

Klon: 1302CT390-118-237

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Titration of the FYN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Flow Cytometry: 1:25,IHC (Paraffin): 1:25,Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the FYN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu FYN

Target: FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))

Andere Bezeichnung: FYN (FYN Produkte)

Synonyme: im:6908851 antikoerper, si:dkey-119m7.5 antikoerper, zgc:109996 antikoerper, c-fyn antikoerper, cfyn-a antikoerper, SLK antikoerper, SYN antikoerper, p59-FYN antikoerper, PKC antikoerper, fyn antikoerper, zgc:86720 antikoerper, AI448320 antikoerper, AW552119 antikoerper, FYN proto-oncogene, Src family tyrosine kinase antikoerper, FYN proto-oncogene, Src family tyrosine kinase S homeolog antikoerper, FYN proto-oncogene, Src family tyrosine kinase b antikoerper, FYN proto-oncogene, Src family tyrosine kinase L homeolog antikoerper, FYN proto-oncogene, Src family tyrosine kinase a antikoerper, Fyn proto-oncogene antikoerper, FYN antikoerper, fyn.S antikoerper, fynb antikoerper, fyn.L antikoerper, Fyn antikoerper, fyna antikoerper

Hintergrund: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta- catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.

UniProt: P06241

Pathways: JAK-STAT Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling