Titration of the ABCB11 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Aliquot the ABCB11 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target
ABCB11
(ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11))
ABCB11 antikoerper, Bsep antikoerper, ABC16 antikoerper, BRIC2 antikoerper, BSEP antikoerper, PFIC-2 antikoerper, PFIC2 antikoerper, PGY4 antikoerper, SPGP antikoerper, Lith1 antikoerper, BSEP/SPGP antikoerper, Spgp antikoerper, ATP binding cassette subfamily B member 11 antikoerper, bile salt export pump antikoerper, ATP-binding cassette, sub-family B (MDR/TAP), member 11 antikoerper, ABCB11 antikoerper, LOC100489744 antikoerper, LOC100565276 antikoerper, EDI_111220 antikoerper, EDI_272930 antikoerper, abcb11 antikoerper, Abcb11 antikoerper
Hintergrund
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.