KCNAB2 Antikörper (N-Term)

Produktnummer ABIN492482

Produktdetails anti-KCNAB2 Antikörper

Target: KCNAB2 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 2 (KCNAB2))

Bindungsspezifität: AA 1-367, N-Term

Reaktivität: Ratte, Human, Maus, Zebrafisch (Danio rerio)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KCNAB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)

Spezifität: Detects a major band at ~38 kDa and a minor band at ~41 kDa.

Produktmerkmale: Synonyms: Voltage-gated potassium channel subunit beta-2, Kv-beta-2, HKvbeta2, KCNA2B, KCNK2

Aufreinigung: Protein G Chromatography.

Immunogen: Fusion protein amino acids 1-367 (full length) of rat Kvbeta-2 (accession numberNP_034728).

Klon: S17-70

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blot: 1 μg/mL1 μg/mL was sufficient for detection of Kvbeta2 in 10 μg of Rat brain lysate by colorimetricimmunoblot analysis using Goat anti-mouse IgG: HRP as the secondary antibody. Immunoprecipitation: 1.0-10 μg/mLImmunofluorescence: 1.0-10 μg/mLImmunocytochemistry: 0.1-1.0 μg/mLImmunohistochemistry: 0.1-1.0 μg/mL
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 containing 50 % Glycerol as stabilizer and 0.09 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu KCNAB2

Target: KCNAB2 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 2 (KCNAB2))

Andere Bezeichnung: KCNAB2 (KCNAB2 Produkte)

Synonyme: kcnab2 antikoerper, KCNAB2 antikoerper, DKFZp459E056 antikoerper, akr6a5 antikoerper, kcna2b antikoerper, kvb-a antikoerper, kvb2 antikoerper, kvbeta2 antikoerper, kvbeta2.1 antikoerper, kvbeta2.2 antikoerper, AKR6A5 antikoerper, HKvbeta2 antikoerper, HKvbeta2.1 antikoerper, HKvbeta2.2 antikoerper, KCNA2B antikoerper, KV-BETA-2 antikoerper, Kvbeta2.1 antikoerper, F5 antikoerper, I2rf5 antikoerper, Kcnb3 antikoerper, kv-beta-2 antikoerper, potassium channel, voltage gated subfamily A regulatory beta subunit 1 antikoerper, potassium voltage-gated channel subfamily A regulatory beta subunit 2 antikoerper, potassium voltage-gated channel, shaker-related subfamily, beta member 2 a antikoerper, potassium channel, voltage gated subfamily A regulatory beta subunit 2 L homeolog antikoerper, voltage-gated potassium channel subunit beta-2 antikoerper, potassium voltage-gated channel, shaker-related subfamily, beta member 2 antikoerper, kcnab1 antikoerper, KCNAB2 antikoerper, kcnab2a antikoerper, kcnab2.L antikoerper, LOC397248 antikoerper, Kcnab2 antikoerper

Hintergrund: Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Depolarization-activated postassium channels (Kv) play a major role in shaping the electrical signals in the nervous system (3). KvBeta2, otherwise known as potassium voltagegated channel, shaker-related subfamily beta member 2, is encoded by the KCNAB2 gene in humans. The KvBeta channels are also members of the aldo-keto reductase (AKR) subfamily. These proteins regulated inactivation and membrane localization of Kv1 and Kv4 channels (4, 5). Specifically Kv2beta2 contributes to regulation of excitability in vivo, although not directly through either chaperone-like or typical AKR catalytic activity (5).Synonyms: HKvbeta2, KCNA2B, KCNK2, Kv-beta-2, Voltage-gated potassium channel subunit beta-2

Gen-ID: 16498

UniProt: P62482