Nischarin Antikörper
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- Target Alle Nischarin (NISCH) Antikörper anzeigen
- Nischarin (NISCH)
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Nischarin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Produktmerkmale
- This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis, possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant protein of human NISCH.
- Isotyp
- IgG
- Top Product
- Discover our top product NISCH Primärantikörper
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- Applikationshinweise
- WB 1:200-1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze/thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C.
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- Target
- Nischarin (NISCH)
- Andere Bezeichnung
- NISCH (NISCH Produkte)
- Synonyme
- NISCH antikoerper, IRAS antikoerper, 1200007D05Rik antikoerper, 3202002H23Rik antikoerper, AW494485 antikoerper, I-1 antikoerper, IR1 antikoerper, hIRAS antikoerper, nischarin antikoerper, nischarin S homeolog antikoerper, NISCH antikoerper, Cyan7822_6841 antikoerper, nisch.S antikoerper, nisch antikoerper, Nisch antikoerper
- Gen-ID
- 11188
- UniProt
- Q9Y2I1
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