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Nischarin Antikörper (AA 5-38)

NISCH Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal RB55910 unconjugated
Produktnummer ABIN6242733
  • Target Alle Nischarin (NISCH) Antikörper anzeigen
    Nischarin (NISCH)
    Bindungsspezifität
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 5-38
    Reaktivität
    • 8
    • 3
    • 1
    Human, Maus
    Wirt
    • 7
    • 3
    Kaninchen
    Klonalität
    • 7
    • 3
    Polyklonal
    Konjugat
    • 10
    Dieser Nischarin Antikörper ist unkonjugiert
    Applikation
    • 8
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This NISCH antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 5-38 amino acids from human NISCH.
    Klon
    RB55910
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product NISCH Primärantikörper
  • Applikationshinweise
    WB: 1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    Nischarin (NISCH)
    Andere Bezeichnung
    NISCH (NISCH Produkte)
    Synonyme
    NISCH antikoerper, IRAS antikoerper, 1200007D05Rik antikoerper, 3202002H23Rik antikoerper, AW494485 antikoerper, I-1 antikoerper, IR1 antikoerper, hIRAS antikoerper, nischarin antikoerper, nischarin S homeolog antikoerper, NISCH antikoerper, Cyan7822_6841 antikoerper, nisch.S antikoerper, nisch antikoerper, Nisch antikoerper
    Hintergrund
    Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
    Molekulargewicht
    166629
    UniProt
    Q9Y2I1
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