RANKL Antikörper (AA 141-318)

Produktnummer ABIN4886751

Produktdetails anti-RANKL Antikörper

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Bindungsspezifität: AA 141-318

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RANKL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Verwendungszweck: Rabbit IgG polyclonal antibody for Tumor necrosis factor ligand superfamily member 11(TNFSF11) detection. Tested with WB, ELISA in Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Tumor necrosis factor ligand superfamily member 11(TNFSF11) detection. Tested with WB, ELISA in Mouse,Rat.
Gene Name: tumor necrosis factor superfamily member 11
Protein Name: Tumor necrosis factor ligand superfamily member 11

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived rat RANKL recombinant protein (Position: F141-D318). Rat RANKL shares 87.9% and 96.6% amino acid (aa) sequence identity with human and mouse RANKL, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat
ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Predicted Species: Rat

Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-RANKL Antikörper (ABIN4886751)

Yang, Zhang, Li, Wen: "MALAT1 enhanced the proliferation of human osteoblasts treated with ultra‑high molecular weight polyethylene by targeting VEGF via miR‑22‑5p." in: International journal of molecular medicine, Vol. 41, Issue 3, pp. 1536-1546, (2018) (PubMed).

Wei, Wang, Gong, Zeng: "Effectiveness of combined salmon calcitonin and aspirin therapy for osteoporosis in ovariectomized rats." in: Molecular medicine reports, Vol. 12, Issue 2, pp. 1717-26, (2016) (PubMed).

Details zu RANKL

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Andere Bezeichnung: TNFSF11 (TNFSF11 Produkte)

Synonyme: CD254 antikoerper, ODF antikoerper, OPGL antikoerper, OPTB2 antikoerper, RANKL antikoerper, TRANCE antikoerper, hRANKL2 antikoerper, sOdf antikoerper, TNFSF11 antikoerper, Ly109l antikoerper, OPG antikoerper, Trance antikoerper, cd254 antikoerper, odf antikoerper, opgl antikoerper, optb2 antikoerper, rankl antikoerper, sodf antikoerper, tnfsf11 antikoerper, trance antikoerper, TNF superfamily member 11 antikoerper, tumor necrosis factor (ligand) superfamily, member 11 antikoerper, TNF receptor superfamily member 11b antikoerper, TNF superfamily member 11 L homeolog antikoerper, TNFSF11 antikoerper, Tnfsf11 antikoerper, TNFRSF11B antikoerper, tnfsf11.L antikoerper

Hintergrund: Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), is a protein that in humans is encoded by the TNFSF11 gene. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. It is mapped to chromosome13q14.11. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. This gene may play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Synonyms: CD254 | hRANKL2 | ODF | OPGL | OPTB2 | Osteoprotegerin ligand | RANKL | sOdf | TNFSF 11 | TNFSF11 | TRANCE | Q9ESE2

Gen-ID: 117516

Pathways: NF-kappaB Signalweg