PREX1 Antikörper (Internal Region)

Produktnummer ABIN453976

Produktdetails anti-PREX1 Antikörper

Target: PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PREX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Canine (Dog) and Cow.
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence C-ERSNLPTDASTTA, from the internal region of Human PREX1 (NP_065871.2).

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: PREX1 antibody Detection limit dilution: 1/6000. Western blot: 1-3 μg/mL. Approx 150 kDa band observed in Human Brain (Temporal Cortex)lysates (calculated MW of 180 kDa according to NP_065871.2).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat, Canine (Dog) and Cow.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu PREX1

Target: PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1))

Andere Bezeichnung: PREX1 (PREX1 Produkte)

Synonyme: MGC68772 antikoerper, P-REX1 antikoerper, G630042G04 antikoerper, Setd6 antikoerper, RGD1306534 antikoerper, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 L homeolog antikoerper, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 antikoerper, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 antikoerper, prex1.L antikoerper, PREX1 antikoerper, prex1 antikoerper, Prex1 antikoerper

Hintergrund: PREX1 functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.Synonyms: 4, 5)-dependent Rac exchanger 1, 5-trisphosphate-dependent Rac exchanger 1 protein, KIAA1415, P-Rex1, Phosphatidylinositol 3, PtdIns(3

Gen-ID: 57580

NCBI Accession: NP_065871

UniProt: Q8TCU6

Pathways: Regulation of Actin Filament Polymerization