KCNQ4 Antikörper (AA 2-77)

Produktnummer ABIN452410

Produktdetails anti-KCNQ4 Antikörper

Target: KCNQ4 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4))

Bindungsspezifität: AA 2-77

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KCNQ4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Spezifität: This antibody detects KCNQ4 K+ Channel at ~77 kDa.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat

Produktmerkmale: Synonyms: KCNQ4, Voltage-gated potassium channel subunit Kv7.4, Potassium channel subunit alphaKvLQT4, KQT-like 4, Potassium voltage-gated channel subfamily KQT member 4

Aufreinigung: Protein G chromatography

Immunogen: Fusion protein amino acid 2-77 of human KCNQ4 (Kv7. 4, KvLQT4)

Klon: S43-6

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blot: 1 - 10 μg/mL (if results are off, try using the lysate without boiling). Immunoprecipitation. Immunocytochemistry: 0.1 - 1.0 μg/mL (Perox).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol and 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu KCNQ4

Target: KCNQ4 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4))

Andere Bezeichnung: KCNQ4 (KCNQ4 Produkte)

Synonyme: KCNQ4 antikoerper, k(v)7.4 antikoerper, kv7.4 antikoerper, DFNA2 antikoerper, DFNA2A antikoerper, KV7.4 antikoerper, potassium voltage-gated channel subfamily Q member 4 antikoerper, potassium channel, voltage gated KQT-like subfamily Q, member 4 antikoerper, potassium voltage-gated channel, subfamily Q, member 4 antikoerper, KCNQ4 antikoerper, kcnq4 antikoerper, Kcnq4 antikoerper

Hintergrund: Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, the protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability (3), particularly in sensory cells of the cochlea (4). The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anticonvulsant drug (5).Synonyms: KCNQ4, KQT-like 4, Potassium channel subunit alpha KvLQT4, Potassium voltage-gated channel subfamily KQT member 4, Voltage-gated potassium channel subunit Kv7.4

Gen-ID: 9132

UniProt: P56696

Pathways: Sensory Perception of Sound