MKNK1 Antikörper (N-Term)

Produktnummer ABIN391226

Produktdetails anti-MKNK1 Antikörper

Target: MKNK1 (MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1))

Bindungsspezifität: AA 1-30, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MKNK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: M

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MKNK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MKNK1.

Klon: RB8561

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu MKNK1

Target: MKNK1 (MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1))

Andere Bezeichnung: MKNK1 (MKNK1 Produkte)

Synonyme: MNK1 antikoerper, MKNK1 antikoerper, zgc:171912 antikoerper, 2410048M24Rik antikoerper, Mnk1 antikoerper, MAPK signal-integrating kinase 1 antikoerper, mknk1 antikoerper, mnk1 antikoerper, MAP kinase interacting serine/threonine kinase 1 antikoerper, MAP kinase-interacting serine/threonine kinase 1 antikoerper, MAP kinase interacting serine/threonine kinase 1 S homeolog antikoerper, MKNK1 antikoerper, mknk1 antikoerper, Mknk1 antikoerper, mknk1.S antikoerper

Hintergrund: MKNK1 encodes a predicted 424-amino acid protein containing a sequence typical of the catalytic domain of serine/threonine kinases and a putative N-terminal nuclear localization signal sequence.C-terminal region of MKNK1 was phosphorylated and activated in vivo and in vitro by ERK1 and p38 MAP kinases, but not by JNK/SAPK. The activated ERK is essential for the activation of MKNK1 in insect cells. MKNK1 was activated following stimulation of HeLa cells with a variety of extracellular stimuli. MNK1 bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2, and also binds strongly to the stress-activated kinase, p38.

Molekulargewicht: 51342

Gen-ID: 8569

NCBI Accession: NP_001129025, NP_003675, NP_945324

UniProt: Q9BUB5

Pathways: MAPK Signalweg, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor