Western Blotting (WB), ELISA, Flow Cytometry (FACS)
Spezifität
Human Tollip, Does not react to TLR2, TLR4, TLR6, TLR7, TLR8 and TLR10 recombinant proteins Tollip, Toll-interacting protein, is a 30 kDa adaptor protein that is a component of the signaling pathway of IL-1 and Toll-like receptors. Tollip forms a complex with IRAK (IL-1 receptor associated kinase) and inhibits IL-1-induced signaling by blocking IRAK phosphorylation. The co-recruitment of MyD88 triggers IRAK autophosphorylation, which in turn leads to the rapid dissociation of IRAK and Tollip. Tollip is also an important signaling component of the TLR2 and TLR4 pathways by playing an inhibitory role in TLR- mediated cell activation. Tollip also associates with Tom1 (target of Myb1) forming a complex which regulates endosomal trafficking of ubiquitinated proteins. 1-6
Working Dilutions: Since applications vary, you should determine the optimum working dilution of the product that is appropriate for your specific need.
Probenmenge
0,2 mL
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
0.5 mg/mL
Buffer
0.1 mg purified immunoglobulin in 0.2 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added
Konservierungsmittel
Without preservative
Handhabung
Each reagent is stable for the period shown on the bottle label if stored as directed.
IL-1RAcPIP antikoerper, 4930403G24Rik antikoerper, 4931428G15Rik antikoerper, fk22a02 antikoerper, im:7145391 antikoerper, wu:fk22a02 antikoerper, zgc:76985 antikoerper, TOLLIP antikoerper, GB17961 antikoerper, tollip antikoerper, tollip1 antikoerper, tollipa antikoerper, TOLIP antikoerper, toll interacting protein antikoerper, toll-interacting protein antikoerper, toll-interacting protein-like antikoerper, toll interacting protein L homeolog antikoerper, toll interacting protein S homeolog antikoerper, Toll-interleukine I receptor interacting protein I antikoerper, TOLLIP antikoerper, Tollip antikoerper, tollip antikoerper, LOC552034 antikoerper, LOC100169858 antikoerper, tollip.L antikoerper, tollip.S antikoerper, LOC100136122 antikoerper
Hintergrund
Toll-interacting protein, is a 30 kDa adaptor protein that is a component of the signaling pathway of IL-1 and Toll-like receptors. Tollip forms a complex with IRAK (IL-1 receptor associated kinase) and inhibits IL-1-induced signaling by blocking IRAK phosphorylation. The co-recruitment of MyD88 triggers IRAK autophosphorylation, which in turn leads to the rapid dissociation of IRAK and Tollip. Tollip is also an important signaling component of the TLR2 and TLR4 pathways by playing an inhibitory role in TLR-mediated cell activation. Tollip also associates with Tom1 (target of Myb1) forming a complex which regulates endosomal trafficking of ubiquitinated proteins.