ARNTL Antikörper (both Isoforms, Internal Region)

Produktnummer ABIN375102

Produktdetails anti-ARNTL Antikörper

Target: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Bindungsspezifität: both Isoforms, Internal Region

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Schwein

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser ARNTL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody is expected to recognize both reported isoforms (NP_001025444.1, NP_001025443.1) of BMAL1

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Bovine, Canine, Pig.
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence REKITTNCYKFKIKD, from the internal region of the protein sequence according to NP_001169.3, NP_001025444.1.

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/8000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu ARNTL

Target: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Andere Bezeichnung: ARNTL / BMAL1 (ARNTL Produkte)

Synonyme: BMAL1 antikoerper, BMAL1c antikoerper, JAP3 antikoerper, MOP3 antikoerper, PASD3 antikoerper, TIC antikoerper, bHLHe5 antikoerper, Bmal1 antikoerper, ARNTL antikoerper, xBmal1 antikoerper, arntl antikoerper, Arnt3 antikoerper, BMAL1b antikoerper, bmal1b' antikoerper, aryl hydrocarbon receptor nuclear translocator like antikoerper, aryl hydrocarbon receptor nuclear translocator-like antikoerper, aryl hydrocarbon receptor nuclear translocator like S homeolog antikoerper, ARNTL antikoerper, Arntl antikoerper, arntl.S antikoerper, arntl antikoerper

Hintergrund: BMAL1 is a putative transcription factor involved in the generation of biological rhythms. It activates cycling transcription of Period (PER) and Timeless (TIM) by binding to the E-box (3'-CACGTG-5') present in their promoters. BMAL1 gene cyc mutants don't display PER and TIM cycling, and are completely arrhythmic. Efficient DNA binding requires dimerization with another bHLH protein, BMAL1 forms a heterodimer with Clock in order to activate PER and TIM transcription.Synonyms: Aryl hydrocarbon receptor nuclear translocator-like protein 1, BHLHE5, Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, Class E basic helix-loop-helix protein 5, MOP3, Member of PAS protein 3, PAS domain-containing protein 3, PASD3, bHLH-PAS protein JAP3, bHLHe5

Gen-ID: 406, 9606

UniProt: O00327

Pathways: Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Warburg Effekt