Neuroserpin Antikörper (C-Term)

Produktnummer ABIN374537

Produktdetails anti-Neuroserpin Antikörper

Target: Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Schimpanse

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Neuroserpin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts to Neuroserpin.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Bovine.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence C-TMNTSGHDFEEL, from the C Terminus of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/32000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Neuroserpin

Target: Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))

Andere Bezeichnung: Neuroserpin / SERPINI1 (SERPINI1 Produkte)

Synonyme: PI12 antikoerper, neuroserpin antikoerper, AI837402 antikoerper, Ns antikoerper, PI-12 antikoerper, Spi17 antikoerper, CG9453 antikoerper, Dmel\\CG9453 antikoerper, Serp2 antikoerper, Sp4 antikoerper, Spn4 antikoerper, Spn4A antikoerper, dSerp2 antikoerper, sp4 antikoerper, spn4 antikoerper, raPIT5a antikoerper, SERPINI1 antikoerper, pi12 antikoerper, serpini1l antikoerper, si:ch211-167c22.4 antikoerper, serpin family I member 1 antikoerper, serine (or cysteine) peptidase inhibitor, clade I, member 1 antikoerper, Serpin 42Da antikoerper, serpin peptidase inhibitor, clade I (neuroserpin), member 1 antikoerper, serpin family I member 1 L homeolog antikoerper, SERPINI1 antikoerper, Serpini1 antikoerper, Spn42Da antikoerper, serpini1 antikoerper, serpini1.L antikoerper

Hintergrund: Neuroserpin is a member of the serpin superfamily and is predominantly expressed by neurons of the developing and adult brain. This serpin is secreted from axonal growth cones of the CNS and PNS where it inhibits the enzyme tissue plasminogen activator. The expression pattern of neuroserpin and its in vivo inhibitory activity implicate this serpin in regulating axonal growth, reducing seizure activity, controlling damage in cerebral infarction and regulating emotional behaviour and memory. Four different mutations have been described in the human neuroserpin gene that promote neuroserpin abnormal polymerization, giving rise to intraneuronal inclusion bodies and a new form of dementia called Familial Encephalopathy with Neuroserpin Inclusion Bodies.Synonyms: PI-12, PI12, Peptidase inhibitor 12, Serpin I1

Gen-ID: 5274, 9606

UniProt: Q99574

Pathways: Regulation of Hormone Metabolic Process