HSD11B1 Antikörper (C-Term)

Produktnummer ABIN374504

Produktdetails anti-HSD11B1 Antikörper

Target: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Bindungsspezifität: C-Term

Reaktivität: Human, Schaf, Rind (Kuh), Schimpanse

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser HSD11B1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: CTSYNMDRFI NK

Spezifität: This antibody is expected to recognise Human HSD11B1 protein. Both NP_005516.1 and NP_861420.1 variants encode the same protein.

Kreuzreaktivität (Details): Species reactivity (expected):Bovine.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography

Immunogen: Peptide with sequence from the C-Terminus of Human HSD11B1 (NP_005516.1, NP_861420.1) Genename: HSD11B1

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/4000. Western Blot: 0.3 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-HSD11B1 Antikörper (ABIN374504)

Liu, Guo, Wang, Zhu, Li, Mi, Myatt, Sun: "Inhibition of Lysyl Oxidase by Cortisol Regeneration in Human Amnion: Implications for Rupture of Fetal Membranes." in: Endocrinology, Vol. 157, Issue 10, pp. 4055-4065, (2017) (PubMed).

Details zu HSD11B1

Target: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Andere Bezeichnung: 11-beta HSD1 / HSD11B1 (HSD11B1 Produkte)

Synonyme: 11-DH antikoerper, 11-beta-HSD1 antikoerper, CORTRD2 antikoerper, HDL antikoerper, HSD11 antikoerper, HSD11B antikoerper, HSD11L antikoerper, SDR26C1 antikoerper, hsd11 antikoerper, hsd11b antikoerper, LRRGT00065 antikoerper, hydroxysteroid 11-beta dehydrogenase 1 antikoerper, hydroxysteroid (11-beta) dehydrogenase 1b antikoerper, hydroxysteroid (11-beta) dehydrogenase 1 L homeolog antikoerper, HSD11B1 antikoerper, HSD11B1b antikoerper, hsd11b1.L antikoerper, Hsd11b1 antikoerper

Hintergrund: HSD11B1 is a microsomal enzyme that catalyses the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyse the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.Synonyms: 11-DH, 11-beta-hydroxysteroid dehydrogenase 1, Corticosteroid 11-beta-dehydrogenase isozyme 1, HSD11, HSD11L

Gen-ID: 3290

NCBI Accession: NP_001193670

UniProt: P28845

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process