PPARD Antikörper (C-Term, Isoform 1)

Produktnummer ABIN374465

Produktdetails anti-PPARD Antikörper

Target: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Bindungsspezifität: C-Term, Isoform 1

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PPARD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: CHPLLQEIYK DMY

Spezifität: This antibody is expected to recognize isoform 1 (NP_006229) of PPAR delta, but not isoform 2, a shorter protein (NP_803184) with a different C-terminus.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Porcine, Bovine.
Species reactivity (tested):Human, Rat.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_006229.1. Genename: PPARD

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/16000. Western blot: 0.3 - 1 μg/mL
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PPARD

Target: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Andere Bezeichnung: PPAR-delta (PPARD Produkte)

Synonyme: FAAR antikoerper, NR1C2 antikoerper, NUC1 antikoerper, NUCI antikoerper, NUCII antikoerper, PPARB antikoerper, NUC-1 antikoerper, Nr1c2 antikoerper, PPAR-beta antikoerper, PPAR-delta antikoerper, PPAR[b] antikoerper, PPARdelta antikoerper, Pparb antikoerper, Pparb/d antikoerper, PPARBETA antikoerper, ppard antikoerper, pparb antikoerper, PPARD antikoerper, PPAR-D/B antikoerper, peroxisome proliferator activated receptor delta antikoerper, peroxisome proliferator activator receptor delta antikoerper, peroxisome proliferator activated receptor delta S homeolog antikoerper, peroxisome proliferator-activated receptor delta antikoerper, PPARD antikoerper, Ppard antikoerper, ppard.S antikoerper, ppard antikoerper

Hintergrund: PPARD is a member of the nuclear hormone receptor subfamily. Upon activation, PPARD forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. PPARD controls genes involved in lipid metabolism, and enhances fatty acid catabolism and energy uncoupling in adipose tissue and skeletal muscle. PPARD has also been implicated in the proliferation and differentiation of preadipocytes, enterocytes, keratinocytes and the placenta. PPARD agonists could be used therapeutically to target multiple components of the metabolic syndrome, including insulin resistance, hyperglycemia, dyslipidemia, and atherosclerosis.Synonyms: NR1C2, NUCI, Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 2, PPAR-beta, PPARB, PPARD, Peroxisome proliferator-activated receptor delta

Gen-ID: 5467

NCBI Accession: NP_001165289

UniProt: Q03181

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Monocarboxylic Acid Catabolic Process, Smooth Muscle Cell Migration, Positive Regulation of fat Cell Differentiation