SORL1 Antikörper (C-Term)

Produktnummer ABIN374076

Produktdetails anti-SORL1 Antikörper

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser SORL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: C-TGFSDDVPMV IA

Spezifität: This antibody detects Sortilin-Related Receptor at C-term.

Kreuzreaktivität (Details): Species reactivity (expected):Human, Rat, Canine (Dog), Bovine.
Species reactivity (tested):Mouse.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide from the C Terminus of the protein according to NP_003096.1. Genename: SORL1

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Limit dilution 1: 32000. Western blot: 0.3-1 μg/mL. Approx 250 kDa band observed in Mouse and Rat Brain lysates(calculated MW of 240 kDa according to Human NP_003096.1, and 240 kDa accordnig toMouse NP_035566.2).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % Sodium Azide, pH 7.3 with 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SORL1

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Andere Bezeichnung: Sortilin-Related Receptor (SORL1) (SORL1 Produkte)

Synonyme: SORL1 antikoerper, C11orf32 antikoerper, LR11 antikoerper, LRP9 antikoerper, SORLA antikoerper, SorLA-1 antikoerper, gp250 antikoerper, SorLA antikoerper, 2900010L19Rik antikoerper, AI596264 antikoerper, AW261561 antikoerper, mSorLA antikoerper, Lr11 antikoerper, RGD619914 antikoerper, sortilin related receptor 1 antikoerper, sortilin-related receptor antikoerper, sortilin-related receptor, L(DLR class) A repeats containing antikoerper, sortilin-related receptor, L(DLR class) A repeats-containing antikoerper, sortilin-related receptor, LDLR class A repeats-containing antikoerper, sorl1 antikoerper, LOC582560 antikoerper, SORL1 antikoerper, Sorl1 antikoerper

Hintergrund: Sortilin-related receptor (SORL1) is likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole, low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.Synonyms: LR11, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, SorLA, SorLA-1, Sorting protein-related receptor containing LDLR class A repeats

Gen-ID: 6653

NCBI Accession: NP_003096

UniProt: Q92673

Pathways: Smooth Muscle Cell Migration