SORL1 Antikörper

Produktnummer ABIN1724674

Produktdetails anti-SORL1 Antikörper

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SORL1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human SORL1 expressed in E. coli.

Klon: 3B6B11

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-SORL1 Antikörper (ABIN1724674)

Shah, Yu: "sorLA: sorting out APP." in: Molecular interventions, Vol. 6, Issue 2, pp. 74-6, 58, (2006) (PubMed).

Gabrielsson, Olofsson, Sjögren, Jernås, Elander, Lönn, Rudemo, Carlsson: "Evaluation of reference genes for studies of gene expression in human adipose tissue." in: Obesity research, Vol. 13, Issue 4, pp. 649-52, (2005) (PubMed).

Scherzer, Offe, Gearing, Rees, Fang, Heilman, Schaller, Bujo, Levey, Lah: "Loss of apolipoprotein E receptor LR11 in Alzheimer disease." in: Archives of neurology, Vol. 61, Issue 8, pp. 1200-5, (2004) (PubMed).

Details zu SORL1

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Andere Bezeichnung: SORL1 (SORL1 Produkte)

Synonyme: SORL1 antikoerper, C11orf32 antikoerper, LR11 antikoerper, LRP9 antikoerper, SORLA antikoerper, SorLA-1 antikoerper, gp250 antikoerper, SorLA antikoerper, 2900010L19Rik antikoerper, AI596264 antikoerper, AW261561 antikoerper, mSorLA antikoerper, Lr11 antikoerper, RGD619914 antikoerper, sortilin related receptor 1 antikoerper, sortilin-related receptor antikoerper, sortilin-related receptor, L(DLR class) A repeats containing antikoerper, sortilin-related receptor, L(DLR class) A repeats-containing antikoerper, sortilin-related receptor, LDLR class A repeats-containing antikoerper, sorl1 antikoerper, LOC582560 antikoerper, SORL1 antikoerper, Sorl1 antikoerper

Hintergrund:

Description: SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

Aliases: SORL1

Gen-ID: 6653

HGNC: 6653

Pathways: Smooth Muscle Cell Migration