Kv2.2 Antikörper

Produktnummer ABIN361380

Produktdetails anti-Kv2.2 Antikörper

Target: Kv2.2 (KCNB2) (Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 2 (KCNB2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Kv2.2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for the ~125k voltage gated potassium channel, Kv 2.2 subunit.

Kreuzreaktivität: Ratte (Rattus)

Aufreinigung: Antigen Affinity Purified from Pooled Serum

Immunogen: Synthetic peptide corresponding to amino acid residues specific to the Kv2.2 subunit conjugated to KLH

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:1000 IHC (frozen sections, unpublished observations): 1:1000 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Referenzen für anti-Kv2.2 Antikörper (ABIN361380)

Gravagna, Knoeckel, Taylor, Hultgren, Ribera: "Localization of Kv2.2 protein in Xenopus laevis embryos and tadpoles." in: The Journal of comparative neurology, Vol. 510, Issue 5, pp. 508-24, (2008) (PubMed).

Details zu Kv2.2

Target: Kv2.2 (KCNB2) (Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 2 (KCNB2))

Andere Bezeichnung: KCNB2 (KCNB2 Produkte)

Synonyme: KCNB2 antikoerper, si:ch211-193n21.1 antikoerper, Kv2.2 antikoerper, 9630047L19Rik antikoerper, BB130875 antikoerper, XShab12 antikoerper, kcnb2 antikoerper, KV2.2 antikoerper, potassium voltage-gated channel subfamily B member 2 antikoerper, potassium voltage-gated channel, Shab-related subfamily, member 2 antikoerper, potassium channel, voltage gated Shab related subfamily B, member 2 antikoerper, potassium voltage gated channel, Shab-related subfamily, member 2 antikoerper, potassium channel, voltage gated Shab related subfamily B, member 2 S homeolog antikoerper, KCNB2 antikoerper, kcnb2 antikoerper, LOC100051372 antikoerper, Kcnb2 antikoerper, kcnb2.S antikoerper

Hintergrund: Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993, Yan et al., 2004, Michaelevski et al., 2003). Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998, Burger and Ribera, 1996). Anti-Voltage Gated Potassium Channel, Kv2.2-Subunit Western blot of rat brain homogenate showing specific immunolabeling of the ~125k voltage-gated potassium channel, Kv2.2 (Control). The immunolabeling is blocked by preadsorption with the peptide used as antigen (Peptide Block).

Molekulargewicht: '100 kDa

Gen-ID: 621349

UniProt: Q63099