TRPA1 Antikörper (4th Cytoplasmic Loop)

Produktnummer ABIN351103

Produktdetails anti-TRPA1 Antikörper

Target: TRPA1 (Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1))

Bindungsspezifität: 4th Cytoplasmic Loop

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRPA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for TRPA1.

Immunogen: A synthetic from the 4th cytoplasmic loop of human transient receptor potential cation channel subfamily A member 1 (TRPA1, ANKTM1) conjugated to an immunogenic carrier protein was used as the immunogen.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu TRPA1

Target: TRPA1 (Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1))

Andere Bezeichnung: TRPA1 (TRPA1 Produkte)

Synonyme: trpa1 antikoerper, ANKTM1 antikoerper, Anktm1 antikoerper, CG5751 antikoerper, CG5761 antikoerper, CT18073 antikoerper, DmTRPA1 antikoerper, Dmel\\CG5751 antikoerper, TRPA antikoerper, TRPA1 antikoerper, TrpA antikoerper, dANKTM1 antikoerper, dTRPA antikoerper, dTRPA1 antikoerper, dTrpA antikoerper, dTrpA1 antikoerper, dtrpA1 antikoerper, trpA1 antikoerper, GLEAN_02449 antikoerper, FEPS antikoerper, transient receptor potential cation channel, subfamily A, member 1a antikoerper, Transient receptor potential cation channel A1 antikoerper, transient receptor potential cation channel subfamily A member 1 antikoerper, transient receptor potential A1 antikoerper, tryptophan synthase subunit alpha 1 antikoerper, transient receptor potential cation channel, subfamily A, member 1 antikoerper, TRPA cation channel homolog antikoerper, trpa1a antikoerper, TrpA1 antikoerper, TRPA1 antikoerper, LOC658860 antikoerper, LOC694623 antikoerper, trpA1 antikoerper, trpa1 antikoerper, Trpa1 antikoerper, trpa-1 antikoerper

Hintergrund: The structure of the protein encoded by this gene is highly related to both the protein ankyrin andtransmembrane proteins. The specific function of this protein has not yet been determined, however, studies indicate the function may involve a role in signal transduction and growth control.
Function: Receptor-activated non-selective cation channel involved in detection of sensations such as cold, pain or sounds perception. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Also involved in pain sensation triggered by capsaicin, the pungent ingredient in chilli peppers. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.
Subcellular location: Membrane, Multi-pass membrane protein (Probable).
Tissue specificity: Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.
Miscellaneous: Inhibited by ruthenium red, a potent blocker of TRPV channels. Also known as: Transient receptor potential cation channel subfamily A member 1, ankyrin-like withtransmembrane domains protein 1, transformation sensitive protein p120, ANKTM1.