Western Blot: 2 - 5g/mL, detects a band of approximately 13 kDa in mouse pancreas tissuelysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
1.0 mg/mL
Vorsichtsmaßnahmen
This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.
Target
HRK
(Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))
DP5 antikoerper, HARAKIRI antikoerper, AI838259 antikoerper, Bid3 antikoerper, harakiri antikoerper, Dp5 antikoerper, harakiri, BCL2 interacting protein antikoerper, harakiri, BCL2 interacting protein (contains only BH3 domain) antikoerper, HRK antikoerper, Hrk antikoerper
Hintergrund
HRK is a BH3 only protein of the Bcl-2 family, which promotes Bax dependent apoptosis. HRK regulates apoptosis through its interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL, and in conjunction to the mitochondrial pore forming protein p32. HRK is thought to have a specific role in initiating neuronal and haematopoietic cell apoptosis, in particular to growth factor deprivation. Aberrant methylation of HRK is frequently detected in primary colorectal cancers. Despite its predicted molecular weight, HRK often migrates at 12-15kD.Synonyms: Activator of apoptosis harakiri, BH3-interacting domain-containing protein 3, BID3, Neuronal death protein DP5