SPTBN1 Antikörper

Produktnummer ABIN317939

Produktdetails anti-SPTBN1 Antikörper

Target: SPTBN1 (Spectrin Beta, Non-Erythrocytic 1 (SPTBN1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPTBN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Spectrin β II antibody detects endogenous levels of Spectrin β II protein.(region surrounding Met687)

Aufreinigung: Affinity chromatography

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SPTBN1

Target: SPTBN1 (Spectrin Beta, Non-Erythrocytic 1 (SPTBN1))

Abstract: SPTBN1 Produkte

Synonyme: 9930031C03Rik antikoerper, AL033301 antikoerper, SPTB2 antikoerper, Spnb-2 antikoerper, Spnb2 antikoerper, elf1 antikoerper, elf3 antikoerper, mKIAA4049 antikoerper, ELF antikoerper, betaSpII antikoerper, Spnb1 antikoerper, spectrin beta, non-erythrocytic 1 antikoerper, spectrin, beta, non-erythrocytic 1 antikoerper, Sptbn1 antikoerper, SPTBN1 antikoerper

Hintergrund: Spectrin is an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin α I and spectrin β I are present in erythrocytes, whereas spectrin α II (also designated fodrin α) and spectrin β II (also designated fodrin β) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Defects in the SPTB gene encoding spectrin β I are the cause of spherocytosis type I (SPH1), a disorder characterized by severe hemolytic anemia. Another disorder due to defects of SPTB is called elliptocytosis or elliptocytosis 3 (EL3). The human SPTB gene maps to chromosome 14q22-q23.2 and encodes the 2,137 amino acid, 246 kDa erythroid form of β-spectrin.Synonyms: Beta-II spectrin, Fodrin beta chain, SPTB2, Spectrin beta chain brain 1, Spectrin non-erythroid beta chain 1

Molekulargewicht: approx. 275 kDa

Gen-ID: 6711

NCBI Accession: NP_003119

UniProt: Q01082

Pathways: Regulation of Actin Filament Polymerization, Protein targeting to Nucleus