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SPTBN1 Antikörper (AA 2101-2189)

SPTBN1 Reaktivität: Human, Maus, Ratte, Hund WB, IF Wirt: Maus Monoclonal 42-B unconjugated
Produktnummer ABIN968882
  • Target Alle SPTBN1 Antikörper anzeigen
    SPTBN1 (Spectrin Beta, Non-Erythrocytic 1 (SPTBN1))
    Bindungsspezifität
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2101-2189
    Reaktivität
    • 26
    • 11
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund
    Wirt
    • 26
    • 1
    Maus
    Klonalität
    • 26
    • 1
    Monoklonal
    Konjugat
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SPTBN1 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 8
    • 5
    • 4
    • 4
    • 4
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Hund, Maus, Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human beta-Spectrin II aa. 2101-2189
    Klon
    42-B
    Isotyp
    IgG1
    Top Product
    Discover our top product SPTBN1 Primärantikörper
  • Applikationshinweise
    For western blot analysis use at 1:1000.
    Kommentare

    Related Products: ABIN968537

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Nicolas, Fournier, Galand, Malbert-Colas, Bournier, Kroviarski, Bourgeois, Camonis, Dhermy, Grandchamp, Lecomte: "Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3527-36, (2002) (PubMed).

    Hu, Watanabe, Bennett: "Characterization of human brain cDNA encoding the general isoform of beta-spectrin." in: The Journal of biological chemistry, Vol. 267, Issue 26, pp. 18715-22, (1992) (PubMed).

    Moon, McMahon: "Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin." in: The Journal of biological chemistry, Vol. 265, Issue 8, pp. 4427-33, (1990) (PubMed).

  • Target
    SPTBN1 (Spectrin Beta, Non-Erythrocytic 1 (SPTBN1))
    Andere Bezeichnung
    beta-Spectrin II (SPTBN1 Produkte)
    Synonyme
    9930031C03Rik antikoerper, AL033301 antikoerper, SPTB2 antikoerper, Spnb-2 antikoerper, Spnb2 antikoerper, elf1 antikoerper, elf3 antikoerper, mKIAA4049 antikoerper, ELF antikoerper, betaSpII antikoerper, Spnb1 antikoerper, spectrin beta, non-erythrocytic 1 antikoerper, spectrin, beta, non-erythrocytic 1 antikoerper, Sptbn1 antikoerper, SPTBN1 antikoerper
    Hintergrund
    Spectrins are central components of the cytoskeleton that form a scaffold below the plasma membrane. Spectrins contain two subunits, alpha and ß, which intertwine to form heterodimers that can self associate into elongated tetramers. alpha-spectin I and ß-spectrin I form heterodimers in red blood cells, while nonerythroid mammalian cells contain heterodimers of alpha-spectin I and II with ß-spectrin I to V. The structure of spectrins includes a succession of triple-helical repeats alongwith various domains, such as SH3 domain, EF hands, PH domains, and binding domains for ankyrin, actin, band 4.1, and calmodulin. alpha-spectrin II is a widely expressed non-erythroid alpha-spectrin that contains an SH3 domain, a calmodulin binding site, and two cleavage sites for proteases, such as calpains and caspase-3. ß-spectrin II is a widely expressed non-erythroid ß-spectrin that contains a C-terminal region that interacts with alpha-spectrins and a PH domain. alpha-spectrin II and ß-spectrin II, like many other spectrins, can form heterodimers that can self associate into tetramers, as well as interact with Band 4.1, F-actin, and other proteins near the plasma membrane. This scaffold of cytoskeletal and plasma membrane proteins is critical for the maintenance of cell structure. This antibody is routinely tested by the Western blot analysis.
    Molekulargewicht
    280 kDa
    Pathways
    Regulation of Actin Filament Polymerization, Protein targeting to Nucleus
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