Endothelin-1 Receptor Antikörper

Produktnummer ABIN317861

Produktdetails anti-Endothelin-1 Receptor Antikörper

Target: Endothelin-1 Receptor (EDNRA) (Endothelin Receptor Type A (EDNRA))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Endothelin-1 Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This antibody detects endogenous levels of ETAR protein.(region surrounding Asp424)

Aufreinigung: Affinity Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1000approx. 1/10000. Western Blot: 1/500approx. 1/1000. Immunofluorescence: 1/50approx. 1/200. Immunohistochemistry: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Endothelin-1 Receptor

Target: Endothelin-1 Receptor (EDNRA) (Endothelin Receptor Type A (EDNRA))

Andere Bezeichnung: Endothelin A Receptor (EDNRA Produkte)

Synonyme: ET-A antikoerper, ETA antikoerper, ETA-R antikoerper, ETAR antikoerper, ETRA antikoerper, hET-AR antikoerper, ET-AR antikoerper, Endor antikoerper, Eta antikoerper, RGD1559432 antikoerper, ETa antikoerper, Gpcr10 antikoerper, ednr-a antikoerper, ednra antikoerper, wu:fb75g12 antikoerper, ednraa antikoerper, eta antikoerper, etar antikoerper, etra antikoerper, zgc:85942 antikoerper, endothelin receptor type A antikoerper, endothelin receptor type Aa antikoerper, endothelin receptor type A L homeolog antikoerper, endothelin receptor type Ab antikoerper, EDNRA antikoerper, Ednra antikoerper, ednraa antikoerper, ednra.L antikoerper, ednra antikoerper, ednrab antikoerper

Hintergrund: Endothelin receptor A (ETAR), also known as EDNRA, ET1 receptor, ETA, EDN1 and ET-AR, is a member of the guanine-binding regulatory protein-coupled receptor family. ETAR binds endothelins and has the highest affinity for its ligand, ET1, as compared to the ETBR receptor. Both ET receptors, ETAR and ETBR, are activated by ET1, which results in inhibition of active lens sodiumpotassium transport. Activation of the ET receptors also causes an increase in cytoplasmic calcium concentration in cultured lens epithelial cells. In addition, ETAR induces arachidonic acid accumulation. ETAR has seven hydrophobic transmembrane domains and is expressed in aorta, lung, atrium, kidney, placenta and prostate. Specifically, placental vascular smooth muscle cells (PVSMCs) exclusively express ETAR.Synonyms: EDNRA, ET-A, ETA, ETA-R, ETRA, Endothelin-1 receptor, endothelin receptor type A, hET-AR

Molekulargewicht: approx. 48 kDa

Gen-ID: 1909

NCBI Accession: NP_001159527

UniProt: P25101

Pathways: cAMP Metabolic Process