FZD8 Antikörper

Produktnummer ABIN317702

Produktdetails anti-FZD8 Antikörper

Target: FZD8 (Frizzled Family Receptor 8 (FZD8))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FZD8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of FDZ8 / Frizzled-8 protein (region surrounding Lys528).

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity-chromatography

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu FZD8

Target: FZD8 (Frizzled Family Receptor 8 (FZD8))

Andere Bezeichnung: FZD8 / Frizzled-8 (FZD8 Produkte)

Synonyme: FZ-8 antikoerper, hFZ8 antikoerper, FZD8 antikoerper, Fz-8 antikoerper, frizzled8 antikoerper, xfz8 antikoerper, Xfz8 antikoerper, frizzled-8 antikoerper, hfz8 antikoerper, Fz8 antikoerper, fzd8 antikoerper, fz5 antikoerper, fz8a antikoerper, fzc antikoerper, wu:fd02c05 antikoerper, zg05 antikoerper, ZG06 antikoerper, Zfz8b antikoerper, fz6 antikoerper, fz8b antikoerper, fzA antikoerper, ik:tdsubc_1e1 antikoerper, xx:tdsubc_1e1 antikoerper, zfzA antikoerper, frizzled class receptor 8 antikoerper, frizzled class receptor 8 S homeolog antikoerper, frizzled class receptor 8 L homeolog antikoerper, frizzled class receptor 8a antikoerper, frizzled class receptor 8b antikoerper, FZD8 antikoerper, fzd8.S antikoerper, fzd8 antikoerper, Fzd8 antikoerper, fzd8.L antikoerper, fzd8a antikoerper, fzd8b antikoerper

Hintergrund: The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several secreted mammalian frizzled-related proteins (FRPs), have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy-terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The cysteine-rich domain of frizzled-8 blocks endogenous Wnts and the effects of Wnt-1 and Wnt-5 on proliferation. The mouse frizzled-8 gene, which encodes a Wnt receptor, is a potent cancer-associated activator of the β-catenin-TCF pathway. The frizzled-8 gene contains no introns. Frizzled-8 mRNA has been detected in fetal brain and kidney, and also in adult pancreas, skeletal muscle, kidney and heart. Frizzled is highly expressed in HeLa S3 (cervical uterus cancer) cells and A549 lung cancer cells.Synonyms: Fz-8, hFz8

Molekulargewicht: approx. 70 kDa

Gen-ID: 8325

NCBI Accession: NP_114072

UniProt: Q9H461

Pathways: WNT Signalweg