ELISA: 1/5000-1/10000. Western Blot: 1/500-1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
1.0 mg/mL
Buffer
PBS, pH ~7.2, 0.05 % Sodium Azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target
Endothelin-1 Receptor (EDNRA)
(Endothelin Receptor Type A (EDNRA))
ET-A antikoerper, ETA antikoerper, ETA-R antikoerper, ETAR antikoerper, ETRA antikoerper, hET-AR antikoerper, ET-AR antikoerper, Endor antikoerper, Eta antikoerper, RGD1559432 antikoerper, ETa antikoerper, Gpcr10 antikoerper, ednr-a antikoerper, ednra antikoerper, wu:fb75g12 antikoerper, ednraa antikoerper, eta antikoerper, etar antikoerper, etra antikoerper, zgc:85942 antikoerper, endothelin receptor type A antikoerper, endothelin receptor type Aa antikoerper, endothelin receptor type A L homeolog antikoerper, endothelin receptor type Ab antikoerper, EDNRA antikoerper, Ednra antikoerper, ednraa antikoerper, ednra.L antikoerper, ednra antikoerper, ednrab antikoerper
Hintergrund
Endothelin receptor A (ETAR), also known as EDNRA, ET1 receptor, ETA, EDN1 and ET-AR, is a member of the guanine-binding regulatory protein-coupled receptor family. ETAR binds endothelins and has the highest affinity for its ligand, ET1, as compared to the ETBR receptor. Both ET receptors, ETAR and ETBR, are activated by ET1, which results in inhibition of active lens sodiumpotassium transport. Activation of the ET receptors also causes an increase in cytoplasmic calcium concentration in cultured lens epithelial cells. In addition, ETAR induces arachidonic acid accumulation. ETAR has seven hydrophobic transmembrane domains and is expressed in aorta, lung, atrium, kidney, placenta and prostate. Specifically, placental vascular smooth muscle cells (PVSMCs) exclusively express ETAR.Synonyms: EDNRA, ET-A, ETA, ETA-R, ETRA, Endothelin-1 receptor, endothelin receptor type A, hET-AR