NOTUM Antikörper

Produktnummer ABIN307025

Produktdetails anti-NOTUM Antikörper

Target: NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOTUM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Maus

Produktmerkmale: Pectinacetylesterase homolog, Wingful (Wf),Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the / -hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.

Aufreinigung: Ammonium Sulfate Precipitation

Immunogen: Rabbits were immunized with recombinant full-length notum protein from mouse.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Antibody can be used for Western blotting (5-10 μg/mL) and immunohistochemistry. Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu NOTUM

Target: NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))

Andere Bezeichnung: Notum (NOTUM Produkte)

Synonyme: 5730593N15Rik antikoerper, RGD1307119 antikoerper, notum, palmitoleoyl-protein carboxylesterase antikoerper, notum pectinacetylesterase homolog (Drosophila) antikoerper, NOTUM, palmitoleoyl-protein carboxylesterase antikoerper, NOTUM antikoerper, Notum antikoerper