FOXP1 Antikörper (C-Term)

Produktnummer ABIN3044456

Produktdetails anti-FOXP1 Antikörper

Target: FOXP1 (Forkhead Box P1 (FOXP1))

Bindungsspezifität: AA 657-677, C-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Forkhead box protein P1(FOXP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequenz: HSPDFDHDRD YEDEPVNEDM E

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Forkhead box protein P1(FOXP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: forkhead box P1
Protein Name: Forkhead box protein P1

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human FOXP1(657-677aa HSPDFDHDRDYEDEPVNEDME),identical to the related rat and mouse sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu FOXP1

Target: FOXP1 (Forkhead Box P1 (FOXP1))

Andere Bezeichnung: FOXP1 (FOXP1 Produkte)

Synonyme: 12CC4 antikoerper, QRF1 antikoerper, hFKH1B antikoerper, 3110052D19Rik antikoerper, 4932443N09Rik antikoerper, AI461938 antikoerper, AW494214 antikoerper, foxp1 antikoerper, im:7139058 antikoerper, wu:fc83a06 antikoerper, FOXP1 antikoerper, MGC145686 antikoerper, 12cc4 antikoerper, fkh1b antikoerper, hspc215 antikoerper, qrf1 antikoerper, xlfoxp1 antikoerper, im:7146611 antikoerper, wu:fb97f01 antikoerper, zgc:154010 antikoerper, forkhead box P1 antikoerper, forkhead box P1b antikoerper, forkhead box P1 S homeolog antikoerper, forkhead box P1a antikoerper, FOXP1 antikoerper, Foxp1 antikoerper, foxp1b antikoerper, foxp1 antikoerper, foxp1.S antikoerper, foxp1a antikoerper

Hintergrund: FOXP1("forkhead box P1") is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors. This gene belongs to subfamily P of the forkhead box(FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region(3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. It was shown that the embryonic stem cell(ESC)-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells. These results reveal a pivotal role for an Alternative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs(2).

Synonyms: 12CC4 antibody|FLJ23741 antibody|Fork head related protein like B antibody|Forkhead box P1 antibody|Forkhead box protein P1 antibody|FOX P1 antibody|FOXP 1 antibody|foxp1 antibody|FOXP1_HUMAN antibody|Glutamine rich factor 1 antibody|hFKH1B antibody|HSPC215 antibody|MGC12942 antibody|MGC88572 antibody|MGC99551 antibody|QRF 1 antibody|QRF1 antibody

UniProt: Q9H334

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response