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MEK1 Antikörper (C-Term)

Dieses Anti-MEK1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MEK1 in WB, IHC und ICC. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN3044391

Kurzübersicht für MEK1 Antikörper (C-Term) (ABIN3044391)

Target

Alle MEK1 (MAP2K1) Antikörper anzeigen
MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

Reaktivität

  • 346
  • 187
  • 180
  • 35
  • 29
  • 19
  • 13
  • 12
  • 12
  • 8
  • 7
  • 5
  • 5
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 312
  • 32
  • 3
  • 2
  • 2
Kaninchen

Klonalität

  • 271
  • 80
Polyklonal

Konjugat

  • 182
  • 19
  • 14
  • 12
  • 11
  • 10
  • 8
  • 8
  • 8
  • 8
  • 8
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 2
  • 2
Dieser MEK1 Antikörper ist unkonjugiert

Applikation

  • 221
  • 114
  • 88
  • 68
  • 66
  • 47
  • 34
  • 26
  • 24
  • 17
  • 15
  • 9
  • 8
  • 7
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 39
    • 28
    • 25
    • 22
    • 21
    • 20
    • 17
    • 16
    • 15
    • 14
    • 10
    • 10
    • 9
    • 8
    • 8
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 353-367, C-Term

    Verwendungszweck

    Anti-MEK1/MAP2K1 Antibody Picoband®

    Sequenz

    KQLMVHAFIK RSDAE

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-MEK1/MAP2K1 Antibody (ABIN3044391). Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human MEK1, identical to the related mouse and rat sequences.

    Isotyp

    IgG
  • Applikationshinweise

    Immunocytochemistry , 0.5-1 μg/mL, Human, -
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, Mouse
    Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
    1. Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA (Mar 1998). "Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5". Cytogenet Cell Genet 78 (3-4): 301-3. 2. Zheng CF, Guan KL (Jun 1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2". J Biol Chem 268 (15): 11435-9.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    Konservierungsmittel

    Thimerosal (Merthiolate), Sodium azide

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

    Andere Bezeichnung

    MAP2K1

    Hintergrund

    Synonyms: Dual specificity mitogen-activated protein kinase kinase 1,MAP kinase kinase 1,MAPKK 1,MKK1,2.7.12.2,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1,MAP2K1,MEK1, PRKMK1,

    Tissue Specificity: Widely expressed, with extremely low levels in brain. .

    Background: Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene. The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon activation by a wide variety of extra- and intracellular signals. As an essential component of the MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. Rampoldi et al. (1997) localized the MAP2K1 gene to 15q22.1-q22.33.

    Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

    Molekulargewicht

    50 kDa

    UniProt

    Q02750

    Pathways

    MAPK Signalweg, RTK Signalweg, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagie, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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