SGK1 Antikörper (N-Term)

Produktnummer ABIN3043433

Produktdetails anti-SGK1 Antikörper

Target: SGK1 (serum/glucocorticoid Regulated Kinase 1 (SGK1))

Bindungsspezifität: AA 28-55, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SGK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase Sgk1(SGK1) detection. Tested with WB in Human.

Sequenz: MKQRRMGLND FIQKIANNSY ACKHPEVQ

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase Sgk1(SGK1) detection. Tested with WB in Human.
Gene Name: serum/glucocorticoid regulated kinase 1
Protein Name: Serine/threonine-protein kinase Sgk1

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human SGK1 (28-55aa MKQRRMGLNDFIQKIANNSYACKHPEVQ), different from the related mouse sequence by three amino acids, and from the related rat sequence by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for SGK1 is approximately 0.1 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-SGK1 Antikörper (ABIN3043433)

Chang, Bok, Sun, Edwards, Huang: "Neuropsin Inactivation Has Protective Effects against Depressive-Like Behaviours and Memory Impairment Induced by Chronic Stress." in: PLoS genetics, Vol. 12, Issue 10, pp. e1006356, (2017) (PubMed).

Details zu SGK1

Target: SGK1 (serum/glucocorticoid Regulated Kinase 1 (SGK1))

Andere Bezeichnung: SGK1 (SGK1 Produkte)

Synonyme: SGK antikoerper, Sgk antikoerper, sgk-B antikoerper, sgk2 antikoerper, cb1083 antikoerper, sgk antikoerper, wu:fc20a09 antikoerper, sgk-A antikoerper, sgk1 antikoerper, sgk1-a antikoerper, sgk1-b antikoerper, serum/glucocorticoid regulated kinase 1 antikoerper, Serine/threonine-protein kinase sgk-1 antikoerper, serum/glucocorticoid regulated kinase 1 S homeolog antikoerper, serum/glucocorticoid regulated kinase 1 L homeolog antikoerper, SGK1 antikoerper, Sgk1 antikoerper, sgk-1 antikoerper, sgk1.S antikoerper, sgk1 antikoerper, sgk1.L antikoerper

Hintergrund: Serine/threonine-protein kinase Sgk1, also called SGK1, encodes a serine/threonine protein kinase that plays an important role in cellular stress response. By fluorescence in situ hybridization, this gene is mapped to 6q23.2. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Synonyms: Serine/threonine protein kinase SGK antibody|Serine/threonine protein kinase Sgk1 antibody| Serine/threonine-protein kinase Sgk1 antibody|Serum and glucocorticoid regulated kinase antibody|Serum/glucocorticoid regulated kinase 1 antibody|Serum/glucocorticoid regulated kinase antibody|Serum/glucocorticoid-regulated kinase 1 antibody|SGK 1 antibody|SGK antibody|SGK1 antibody|SGK1_HUMAN antibody

Gen-ID: 6446

UniProt: O00141

Pathways: MAPK Signalweg, Notch Signalweg, Steroid Hormone Mediated Signaling Pathway