Caspase 7 Antikörper (Middle Region)

Produktnummer ABIN3043217

Produktdetails anti-Caspase 7 Antikörper

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Bindungsspezifität: AA 237-255, Middle Region

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Caspase-7(CASP7) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequenz: RGSWFVQALC SILEEHGKD

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Caspase-7(CASP7) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: caspase 7, apoptosis-related cysteine peptidase
Protein Name: Caspase-7(CASP-7)

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Caspase-7(P11)(237-255aa RGSWFVQALCSILEEHGKD), different from the related mouse and rat sequences by two amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Caspase 7

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Andere Bezeichnung: CASP7 (CASP7 Produkte)

Synonyme: xCaspase-7 antikoerper, caspase-7 antikoerper, caspase7 antikoerper, cmh-1 antikoerper, ice-lap3 antikoerper, mch3 antikoerper, CASP7 antikoerper, AI314680 antikoerper, CMH-1 antikoerper, ICE-IAP3 antikoerper, Mch3 antikoerper, mCASP-7 antikoerper, CASP-7 antikoerper, ICE-LAP3 antikoerper, LICE2 antikoerper, MCH3 antikoerper, Caspase-7 antikoerper, MCH3/SCA-2 antikoerper, SCA-2 antikoerper, caspase 7 antikoerper, caspase-7 antikoerper, caspase 7 S homeolog antikoerper, CASP7 antikoerper, xcaspase-7 antikoerper, casp7 antikoerper, casp7.S antikoerper, Casp7 antikoerper

Hintergrund: CASP7, Caspase-7, apoptosis-related cysteine peptidase, is a human protein encoded by the CASP7 gene. CASP7 orthologs have been identified in nearly all mammals for which complete genome data are available. CASP7 is a member of the caspase(cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Using radiation hybrid mapping, the CASP7 gene was localized to human chromosome 10q25.1-q25.2. The orderly activation of CASP7 regulates microglia activation through a protein kinase C-delta(PRKCD)-dependent pathway.

Synonyms: Apoptosis related cysteine peptidase antibody|Apoptosis Related Cysteine Protease antibody|Apoptotic protease Mch-3 antibody|Apoptotic Protease MCH3 antibody|CASP 7 antibody|CASP-7 antibody|CASP7 antibody|Caspase-7 subunit p11 antibody|Caspase7 antibody|CMH 1 antibody|CMH-1 antibody|CMH1 antibody|ICE LAP3 antibody|ICE like Apoptotic Protease 3 antibody|ICE-LAP3 antibody|ICE-like apoptotic protease 3 antibody|MCH3 antibody

UniProt: P55210

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity