Phospholamban Antikörper (N-Term)

Produktnummer ABIN3032227

Produktdetails anti-Phospholamban Antikörper

Target: Phospholamban (PLN)

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Phospholamban Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human Phospholamban (EKVQYLTRSAIRRAS) was used as the immunogen for this Phospholamban antibody (100% homologous in human, mouse and rat).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the Phospholamban antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Phospholamban antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Phospholamban

Target: Phospholamban (PLN)

Andere Bezeichnung: Phospholamban (PLN Produkte)

Synonyme: LOC100226261 antikoerper, plb antikoerper, cmd1p antikoerper, CMD1P antikoerper, CMH18 antikoerper, PLB antikoerper, Plb antikoerper, Plm antikoerper, phospholamban antikoerper, PLN antikoerper, pln antikoerper, Pln antikoerper

Hintergrund: Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. McTiernan et al.(1999) observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity