IRF4 Antikörper (AA 272-451)

Produktnummer ABIN3031419

Produktdetails anti-IRF4 Antikörper

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Bindungsspezifität: AA 272-451

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Human partial recombinant protein (AA 272-451) was used as the immunogen for this IRF4 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the IRF4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the IRF4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu IRF4

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Andere Bezeichnung: IRF4 (MUM1) (IRF4 Produkte)

Synonyme: LSIRF antikoerper, MUM1 antikoerper, NF-EM5 antikoerper, AI385587 antikoerper, IRF-4 antikoerper, Spip antikoerper, IRF4 antikoerper, si:ch73-170d1.2 antikoerper, irf4 antikoerper, interferon regulatory factor 4 antikoerper, interferon regulatory factor 4a antikoerper, Interferon regulatory factor 4 antikoerper, PWWP domain-containing protein MUM1 antikoerper, IRF4 antikoerper, Irf4 antikoerper, irf4a antikoerper, irf4 antikoerper, LOC612320 antikoerper, LOC100068881 antikoerper

Hintergrund: Interferon regulatory factor 4, also known as MUM1, is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. Additionally, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.

Gen-ID: 3662

Pathways: Chromatin Binding